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尼马瑞韦/利托那韦片减少了成年门诊患者的 COVID-19 住院和长新冠的发生。

Nirmatrelvir plus ritonavir reduces COVID-19 hospitalization and prevents long COVID in adult outpatients.

机构信息

Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.

出版信息

Sci Rep. 2024 Oct 29;14(1):25901. doi: 10.1038/s41598-024-76472-0.

Abstract

Nirmatrelvir plus ritonavir received Emergency Use Authorization for treating mild to moderate COVID-19 in high-risk patients. Its efficacy against the Omicron variant of SARS-CoV-2 remains uncertain. This retrospective cohort study assessed the effect of nirmatrelvir-ritonavir in preventing severe disease progression and long COVID symptoms after acute COVID-19 in non-hospitalized adults. SALAMA medical records from Dubai's COVID-19 healthcare centers between May 22, 2022, and April 30, 2023, were used to identify 7290 eligible patients, 9.6% of whom received nirmatrelvir-ritonavir. Treatment was associated with a notable reduction in COVID-19-related hospitalizations (adjusted hazard ratio [HR] of 0.39; 95% CI, 0.18-0.85) by day 28 of symptom onset. Moreover, nirmatrelvir-ritonavir was associated with fewer long COVID symptoms (adjusted HR of 0.42; 95% CI, 0.19-0.95). This suggests the significant effectiveness of nirmatrelvir-ritonavir against the Omicron variant, reducing both severe and long-term COVID-19 symptoms.

摘要

尼马瑞韦(nirmatrelvir)加利托那韦(ritonavir)获得了治疗高危人群轻中度 COVID-19 的紧急使用授权。它对 SARS-CoV-2 的奥密克戎变体的疗效仍不确定。这项回顾性队列研究评估了尼马瑞韦加利托那韦在预防非住院成人急性 COVID-19 后严重疾病进展和长新冠症状方面的效果。研究使用了 2022 年 5 月 22 日至 2023 年 4 月 30 日迪拜 COVID-19 医疗中心的 SALAMA 病历,确定了 7290 名符合条件的患者,其中 9.6%的患者接受了尼马瑞韦加利托那韦治疗。与症状出现第 28 天相比,治疗与 COVID-19 相关住院的显著减少有关(调整后的危险比 [HR] 为 0.39;95%置信区间,0.18-0.85)。此外,尼马瑞韦加利托那韦与较少的长新冠症状相关(调整后的 HR 为 0.42;95%置信区间,0.19-0.95)。这表明尼马瑞韦加利托那韦对奥密克戎变体的有效性显著,降低了严重和长期 COVID-19 症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8896/11522512/51b86138c40d/41598_2024_76472_Fig1_HTML.jpg

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