转移性和非转移性神经疾病患者的脑脊液癌胚抗原

Cerebrospinal fluid carcinoembryonic antigen in patients with metastatic and nonmetastatic neurological diseases.

作者信息

Twijnstra A, Nooyen W J, van Zanten A P, Hart A A, Ongerboer de Visser B W

出版信息

Arch Neurol. 1986 Mar;43(3):269-72. doi: 10.1001/archneur.1986.00520030059015.

DOI:10.1001/archneur.1986.00520030059015

Abstract

Cerebrospinal fluid (CSF) carcinoembryonic antigen (CEA) values were determined in 200 patients suffering from various neurological diseases. We found no relationship between CEA levels and age or sex. A positive test was defined as an upper limit of at least 4.0 ng/mL of CEA. We found raised CSF CEA levels in patients with leptomeningeal spread from carcinoma, but not in patients with leptomeningeal metastases from lymphoma. We also found high values of CSF CEA in three of 21 patients with epidural metastases and in two of 28 patients with cerebral metastases from solid tumors. Comparison was made with the CSF levels of total protein, glucose, and lactate dehydrogenase. The sensitivity of the CSF CEA determination in patients for the presence of leptomeningeal involvement of cancer is 31% and the specificity is 90%.

摘要

对200例患有各种神经系统疾病的患者测定了脑脊液（CSF）癌胚抗原（CEA）值。我们发现CEA水平与年龄或性别之间没有关系。阳性检测定义为CEA至少4.0 ng/mL的上限。我们发现癌性软脑膜播散患者的脑脊液CEA水平升高，但淋巴瘤性软脑膜转移患者未升高。我们还发现，21例硬膜外转移患者中有3例以及28例实体瘤脑转移患者中有2例的脑脊液CEA值较高。将其与脑脊液总蛋白、葡萄糖和乳酸脱氢酶水平进行了比较。脑脊液CEA测定对癌症软脑膜受累患者的敏感性为31%，特异性为90%。