Diagnostic and Interventional Radiology, University Hospitals Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Urology, Hegau-Bodensee-Klinikum, Singen, Germany.
BMC Musculoskelet Disord. 2024 Oct 29;25(1):858. doi: 10.1186/s12891-024-07971-4.
Sitting is known to be bad for your cardiovascular health. We furthermore hypothesized that sitting posture will reduce perfusion of the foot and increase edema, possibly predisposing to disease like osteochondritis.
We included 27 healthy volunteers and performed MRI measurements including arterial spin labelling (ASL) and intravoxel incoherent motion (IVIM) perfusion as well as short tau inversion recovery (STIR) edema measurement and 3D volumetry. After randomization, the elevation of one foot during the day was used as an intervention.
Intra- and interrater variability was 1-6%. ASL perfusion measurement was hindered by artifacts. IVIM perfusion showed no significant changes during supine measurements. Volumetry could demonstrate a highly significant (p = 0.00005) volume increase, while the intervention led to a significant (p = 0.0076) volume decrease during the day. However, the water content in STIR remained unchanged and the normalized (quotient bone/muscle) edema was reduced on the control side (p = 0.006) and increased on the intervention side (p = 0.01).
Sitting all day leads to swelling of the healthy foot. Compensation in healthy subjects seems to prevent lasting perfusion changes or edema evolution in the bone despite an increase of muscle signal and volume increase. Thus, the etiology of osteochondritis needs further studies.
久坐已被证实不利于心血管健康。我们进一步假设坐姿会减少足部灌注并增加水肿，可能导致骨软骨炎等疾病。
我们纳入了 27 名健康志愿者，并进行了 MRI 测量，包括动脉自旋标记（ASL）和体素内不相干运动（IVIM）灌注以及短 tau 反转恢复（STIR）水肿测量和 3D 容积测量。随机分组后，白天抬高一只脚作为干预。
组内和组间的可变性为 1-6%。ASL 灌注测量受到伪影的阻碍。IVIM 灌注在仰卧位测量时没有显著变化。容积测量可以显示出非常显著的（p=0.00005）体积增加，而干预导致白天的体积显著（p=0.0076）减少。然而，STIR 中的水含量保持不变，且在对照组（p=0.006）中，标准化（骨/肌肉比值）水肿减少，在干预组（p=0.01）中增加。
整天坐着会导致健康脚肿胀。尽管肌肉信号增加和体积增加，但健康受试者的代偿似乎可以防止持续的灌注变化或骨水肿进展。因此，骨软骨炎的病因需要进一步研究。
