血清 miR-513a-3p 联合动脉血气分析参数及肺部超声评分对新生儿呼吸窘迫综合征的临床评估。

Clinical evaluation of serum miR-513a-3p combined with arterial blood gas analysis parameters and lung ultrasound score in neonatal respiratory distress syndrome.

机构信息

Department of Ultrasound Medicine, The First Affiliated Hospital of Shihezi University, No. 107, Community 32, North Second Road, Shihezi, 832008, China.

Department of Neurosurgery, Hui Autonomous Prefecture People's Hospital, Changji, 831100, China.

出版信息

Ital J Pediatr. 2024 Oct 29;50(1):227. doi: 10.1186/s13052-024-01795-7.

DOI:10.1186/s13052-024-01795-7

PMID:39472946

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11523833/

Abstract

BACKGROUND

Neonatal respiratory distress syndrome (NRDS) is harmful to neonates and the prognosis is variable, ranging from mild to severe forms. This study aims to evaluate the clinical utility of miR-513a-3p in conjunction with arterial blood gas analysis parameters and lung ultrasound (LUS) score in the context of NRDS.

METHODS

The study included 169 preterm infants, including 106 newborns with NRDS and 63 newborns without NRDS. The relative expression level of miR-513a-3p was detected by quantitative real time polymerase chain reaction (qRT-PCR). Umbilical artery blood gas parameter values and LUS score were recorded, and the clinical significance of miR-513a-3p, umbilical artery blood gas parameter and LUS score in NRDS were evaluated by Receiver Operating Characteristic (ROC) analysis.

RESULTS

Elevated levels of miR-513a-3p were detected in the serum of NRDS, and higher expression of miR-513a-3p was observed in individuals with poor prognosis. Notably, miR-513a-3p exhibited a significant correlation with the parameters of arterial blood gas analysis and LUS score in NRDS patients. Furthermore, miR-513a-3p was one of the risk factors for poor prognosis in NRDS patients. miR-513a-3p levels combined with umbilical artery blood gas parameters and LUS score has diagnostic value for NRDS and is reliable for its prognosis.

CONCLUSIONS

Elevated levels of miR-513a-3p in neonatal serum served as a useful tool in the combined assessment with umbilical artery blood gas analysis and LUS score to diagnosis and prognosis of NRDS. Consequently, miR-513a-3p may be served as a biomarker for diagnosis and prognosis of NRDS.

摘要

背景

新生儿呼吸窘迫综合征（NRDS）对新生儿有害，其预后各不相同，从轻症到重症不等。本研究旨在评估 miR-513a-3p 联合动脉血气分析参数和肺部超声（LUS）评分在 NRDS 中的临床应用价值。

方法

本研究纳入了 169 例早产儿，包括 106 例 NRDS 新生儿和 63 例非 NRDS 新生儿。通过实时定量聚合酶链反应（qRT-PCR）检测 miR-513a-3p 的相对表达水平。记录脐动脉血气参数值和 LUS 评分，并通过受试者工作特征（ROC）分析评估 miR-513a-3p、脐动脉血气参数和 LUS 评分在 NRDS 中的临床意义。

结果

NRDS 患儿血清中 miR-513a-3p 水平升高，且预后不良者 miR-513a-3p 表达水平更高。值得注意的是，miR-513a-3p 与 NRDS 患者的动脉血气分析参数和 LUS 评分显著相关。此外，miR-513a-3p 是 NRDS 患者预后不良的危险因素之一。miR-513a-3p 联合脐动脉血气参数和 LUS 评分对 NRDS 具有诊断价值，且对其预后可靠。