Department of Pathology, Jinhua Municipal Central Hospital, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, 321000, China.
Department of Radiation Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Radiat Oncol. 2024 Oct 29;19(1):149. doi: 10.1186/s13014-024-02535-1.
Magnetic resonance imaging is indispensable for the preoperative diagnosis of glioma. This study aimed to investigate the role of the apparent diffusion coefficient values as predictors of survival in patients with gliomas.
A retrospective analysis was conducted on 101 patients with gliomas who underwent surgery between 2015 and 2020. Diffusion-weighted MRI was performed before the surgery. The regions of interest were categorized into parenchymal area, non-enhancing peritumoral area, and necrotic or cystic area. All the patients were divided into three subgroups: the parenchyma group, the non-enhancing peritumoral signal abnormality group, and the necrosis or cyst group. Univariate and multivariate analyses were performed using COX regression.
In the parenchymal group, Ki67, P53, IDH, and the high or low ADC values were identified as independent prognosticators for disease-free survival, while Ki67, IDH, and the high or low ADC values for overall survival. In the non-enhancing peritumoral signal abnormality group, Ki67, P53, IDH, and the ADC /ADC ratio were identified as independent prognostic factors for disease-free survival, while Ki67, IDH, and the ADC /ADC ratio for overall survival. In the necrosis or cyst group, Ki67 was significantly associated with disease-free survival, while Ki67 and the ADC value of the necrotic or cystic area for overall survival.
The ADC values, including the ADC value in the parenchymal area, the ADC /ADC ratio, and the ADC value in the necrotic or cystic area, can serve as an efficient and potential index for predicting the survival of patients with glioma.
磁共振成像对于脑胶质瘤的术前诊断是不可或缺的。本研究旨在探讨表观扩散系数值作为预测脑胶质瘤患者生存的作用。
回顾性分析了 2015 年至 2020 年间接受手术的 101 例脑胶质瘤患者。所有患者均在术前进行了弥散加权 MRI 检查。感兴趣区分为实质区、非增强瘤周信号异常区和坏死或囊性区。所有患者分为三组：实质组、非增强瘤周信号异常组和坏死或囊性组。采用 COX 回归进行单因素和多因素分析。
在实质组中，Ki67、P53、IDH 和高或低 ADC 值被确定为无病生存的独立预后因素，而 Ki67、IDH 和高或低 ADC 值则是总生存的独立预后因素。在非增强瘤周信号异常组中，Ki67、P53、IDH 和 ADC/ADC 比值被确定为无病生存的独立预后因素，而 Ki67、IDH 和 ADC/ADC 比值则是总生存的独立预后因素。在坏死或囊性组中，Ki67 与无病生存显著相关，而 Ki67 和坏死或囊性区的 ADC 值与总生存相关。
ADC 值，包括实质区的 ADC 值、ADC/ADC 比值和坏死或囊性区的 ADC 值，可以作为预测脑胶质瘤患者生存的有效且有潜力的指标。
