Kaplan H J, Waldrep J C, Chan W C, Nicholson J K, Wright J D
Arch Ophthalmol. 1986 Feb;104(2):240-4. doi: 10.1001/archopht.1986.01050140094028.
The inflammatory cell reaction within the vitreous and uvea of a human eye with atypical sympathetic ophthalmia was studied immunohistologically and with the fluorescence-activated cell sorter. The uveal infiltrate consisted predominantly of T cells of the helper/inducer subset, with less than 5% of the cells characterized as B cells, plasma cells, or monocytes. These results suggest that T cells perform an important role in atypical human sympathetic ophthalmia. A similar population of mononuclear cells was observed in the vitreous inflammatory infiltrate, in marked contrast to the peripheral blood, where there was a significant depression of circulating T cells. The similarity between the inflammatory cell populations within the vitreous cavity and uvea, in contrast to the peripheral blood, underlines the importance of studying the intraocular inflammatory reaction in uveitis to gain further insight into the mechanism of this disease.
利用免疫组织学方法及荧光激活细胞分选仪，对患有非典型交感性眼炎的人眼玻璃体和葡萄膜内的炎性细胞反应进行了研究。葡萄膜浸润主要由辅助/诱导亚群的T细胞组成，特征为B细胞、浆细胞或单核细胞的细胞占比不到5%。这些结果表明，T细胞在非典型人类交感性眼炎中发挥着重要作用。在玻璃体炎性浸润中观察到了类似的单核细胞群，这与外周血形成了显著对比，外周血中循环T细胞明显减少。与外周血相比，玻璃体腔和葡萄膜内炎性细胞群的相似性突出了研究葡萄膜炎眼内炎症反应对于深入了解该疾病机制的重要性。
