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肝癌患者的心血管死亡风险:一项监测、流行病学和最终结果(SEER)数据库研究

Cardiovascular Mortality Risk among Patients with Liver Cancer: A SEER Database Study.

作者信息

Li Juan, Zhang Junyong, He Song

机构信息

The Second Affiliated Hospital of Chongqing Medical University, Department of Gastroenterology, China.

The Second Affiliated Hospital of Chongqing Medical University, Department of Urology, China.

出版信息

Curr Cancer Drug Targets. 2024 Oct 28. doi: 10.2174/0115680096321687240912111652.

Abstract

UNLABELLED

Crucial for understanding their overall health outcomes. This research aimed to as-sess the CVM risk of liver cancer patients.

METHODS AND MATERIALS

Data sourced from the Surveillance, Epidemiology, and End Results (SEER) database encompassing liver cancer diagnoses from 2000 to 2017 were utilized. The standardized mortality rate (SMR) was computed using general population reference data, and multivariate competing risk models were employed for analysis.

RESULTS

Analysis of 70,733 liver cancer patient records revealed 1,954 instances of CVM. The overall CVM SMR for liver cancer patients was 12.01 (95% CI: 11.48-12.55). Various demographic and clinical factors, including sex, race, age, year of diagnosis, pathological type, general stage, treatment modalities, and matrimonial status, emerged as liver cancer pa-tients` independent predictors of CVM.

CONCLUSION

Liver cancer patients have a notably heightened susceptibility to cardiovascular mortality (CVM) in contrast to the general populace. It is imperative to promptly recognize high-risk subcategories and execute tailored cardiovascular interventions as crucial measures to bolster survival rates within this cohort of patients.

摘要

未标注

对于了解他们的总体健康结果至关重要。本研究旨在评估肝癌患者的心血管疾病死亡率(CVM)风险。

方法和材料

使用了来自监测、流行病学和最终结果(SEER)数据库的数据,该数据库涵盖了2000年至2017年的肝癌诊断病例。使用一般人群参考数据计算标准化死亡率(SMR),并采用多变量竞争风险模型进行分析。

结果

对70733例肝癌患者记录的分析显示有1954例心血管疾病事件。肝癌患者的总体心血管疾病死亡率标准化死亡率为12.01(95%置信区间:11.48 - 12.55)。各种人口统计学和临床因素,包括性别、种族、年龄、诊断年份、病理类型、总体分期、治疗方式和婚姻状况,成为肝癌患者心血管疾病事件的独立预测因素。

结论

与一般人群相比,肝癌患者患心血管疾病死亡(CVM)的易感性显著增加。必须及时识别高危亚组并实施针对性的心血管干预措施,作为提高该患者群体生存率的关键措施。

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