Diniz Micael Oliveira, Khalil Mohammad, Fagman Erika, Vikgren Jenny, Haj Faiz, Svalkvist Angelica, Båth Magnus, Johnsson Åse Allansdotter
University of Gothenburg, Sahlgrenska Academy, Institute of Clinical Sciences, Department of Radiology, Gothenburg, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden.
J Med Imaging (Bellingham). 2025 Jan;12(Suppl 1):S13007. doi: 10.1117/1.JMI.12.S1.S13007. Epub 2024 Oct 28.
We aim to investigate the localization, visibility, and measurement of lung nodules in digital chest tomosynthesis (DTS).
Computed tomography (CT), maximum intensity projections (CT-MIP) (transaxial versus coronal orientation), and computer-aided detection (CAD) were used as location reference, and inter- and intra-observer agreement regarding lung nodule size was assessed. Five radiologists analyzed DTS and CT images from 24 participants with lung , focusing on lung nodule localization, visibility, and measurement on DTS. Visual grading was used to compare if coronal or transaxial CT-MIP better facilitated the localization of lung nodules in DTS.
The majority of the lung nodules (79%) were rated as visible in DTS, although less clearly in comparison with CT. Coronal CT-MIP was the preferred orientation in the task of locating nodules on DTS. On DTS, area-based lung nodule size estimates resulted in significantly less measurement variability when compared with nodule size estimated based on mean diameter (mD) ( ). Also, on DTS, area-based lung nodule size estimates were more accurate ( ) than lung nodule size estimates based on mean diameter ( ).
Coronal CT-MIP images are superior to transaxial CT-MIP images in facilitating lung nodule localization in DTS. Most found on CT can be visualized, correctly localized, and measured in DTS, and area-based measurement may be the key to more precise and less variable nodule measurements on DTS.
我们旨在研究数字胸部断层合成（DTS）中肺结节的定位、可视性及测量。
使用计算机断层扫描（CT）、最大密度投影（CT-MIP）（横轴位与冠状位方向）以及计算机辅助检测（CAD）作为定位参考，并评估观察者间及观察者内关于肺结节大小的一致性。五位放射科医生分析了24名肺部疾病患者的DTS和CT图像，重点关注DTS上肺结节的定位、可视性及测量。采用视觉分级来比较冠状位或横轴位CT-MIP是否更有助于在DTS中定位肺结节。
大多数肺结节（79%）在DTS中被评为可见，尽管与CT相比清晰度稍差。冠状位CT-MIP是在DTS上定位结节任务中的首选方向。在DTS上，与基于平均直径（mD）估计的结节大小相比，基于面积的肺结节大小估计导致的测量变异性显著更小（ ）。此外，在DTS上，基于面积的肺结节大小估计比基于平均直径的肺结节大小估计更准确（ ）。
在促进DTS中肺结节定位方面，冠状位CT-MIP图像优于横轴位CT-MIP图像。在CT上发现的大多数 可以在DTS中可视化、正确定位并测量，基于面积的测量可能是在DTS上进行更精确且变异性更小的结节测量的关键。
