普鲁卡因对犬心肌组织缺氧诱导异常的影响。

Effects of procaine on hypoxia induced abnormalities in canine myocardial tissues.

作者信息

Bhattacharyya M L, Acharya S

出版信息

Biochem Biophys Res Commun. 1986 Jan 29;134(2):900-6. doi: 10.1016/s0006-291x(86)80505-8.

Abstract

Combined effects of hypoxia, hyperkalemia and acidosis (HH&A) produced contracture (increased resting tension) in canine ventricular muscle tissues but not in Purkinje fibers perfused for the same length of time. Administration of procaine during such contracture stabilized the resting tension somewhat. High [Ca]o during HH&A causes contracture to appear much sooner. On return to oxygenated tyrode oscillatory after potentials (or oscillations in diastole) developed in ventricular muscles, and these oscillations disappeared in the presence of procaine.

摘要

缺氧、高钾血症和酸中毒（HH&A）的联合作用可使犬心室肌组织发生挛缩（静息张力增加），但在相同灌注时间的浦肯野纤维中却不会出现这种情况。在这种挛缩过程中给予普鲁卡因可使静息张力有所稳定。HH&A期间高[Ca]o会使挛缩出现得更早。当恢复到充氧的台氏液时，心室肌会出现振荡后电位（或舒张期振荡），而在普鲁卡因存在的情况下这些振荡会消失。