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使用离子液体/镍钴层状双氢氧化物纳米片修饰的碳糊电极作为伏安传感器测定甲氨蝶呤。

Determination of methotrexate using carbon paste electrode modified with ionic liquid/Ni-Co layered double hydroxide nanosheets as a voltammetric sensor.

作者信息

Mohammadzadeh Jahani Peyman, Garkani Nejad Fariba, Zaimbashi Reza, Aflatoonian Mohammad Reza, Tajik Somayeh, Beitollahi Hadi

机构信息

School of Medicine, Bam University of Medical Sciences, Bam, Iran.

Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.

出版信息

ADMET DMPK. 2024 Sep 4;12(4):637-648. doi: 10.5599/admet.2460. eCollection 2024.

DOI:10.5599/admet.2460
PMID:39473626
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11517520/
Abstract

BACKGROUND AND PURPOSE

Methotrexate (MTX) is a widely used anti-cancer drug, but its overuse can lead to significant side effects. Therefore, it is very vital to design simple and sensitive analytical methods for its determination.

EXPERIMENTAL APPROACH

In this work, an electrochemical sensor was prepared based on an ionic liquid (IL)/Ni-Co layered double hydroxide nanosheets (Ni-Co-LDH)-modified carbon paste electrode IL/Ni-Co-LDH/CPE. Cyclic voltammetry, differential pulse voltammetry, and chronoamperometry methods were applied to evaluate the performance of the designed sensor for MTX determination.

KEY RESULTS

The IL/Ni-Co-LDH/CPE sensor exhibits a linear relationship between the peak current of the differential pulse voltammetry and MTX concentrations in the linear dynamic range of 0.02 to 140.0 μM, with a detection limit of 0.006 μM. The IL/Ni-Co-LDH/CPE sensor exhibited relative standard deviation values between 1.7 to 3.7 % for recovery tests on real samples, indicating the precision of the method.

CONCLUSION

The designed sensor with cost-effective and good performance could be valuable for therapeutic drug monitoring and clinical diagnostics.

摘要

背景与目的

甲氨蝶呤（MTX）是一种广泛使用的抗癌药物，但其过度使用会导致严重的副作用。因此，设计简单灵敏的分析方法来测定它非常重要。

实验方法

在这项工作中，基于离子液体（IL）/镍钴层状双氢氧化物纳米片（Ni-Co-LDH）修饰的碳糊电极IL/Ni-Co-LDH/CPE制备了一种电化学传感器。采用循环伏安法、差分脉冲伏安法和计时电流法来评估所设计传感器测定MTX的性能。

关键结果

IL/Ni-Co-LDH/CPE传感器在0.02至140.0μM的线性动态范围内，差分脉冲伏安法的峰电流与MTX浓度之间呈现线性关系，检测限为0.006μM。IL/Ni-Co-LDH/CPE传感器对实际样品进行回收率测试时，相对标准偏差值在1.7%至3.7%之间，表明该方法的精密度。

结论

所设计的传感器具有成本效益且性能良好，对治疗药物监测和临床诊断可能具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/a159130cef03/ADMET-12-2460-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/e2750904d639/ADMET-12-2460-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/e301c983e6af/ADMET-12-2460-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/7a5b8375e5a9/ADMET-12-2460-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/cdb452ccb267/ADMET-12-2460-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/a159130cef03/ADMET-12-2460-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/e2750904d639/ADMET-12-2460-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/e301c983e6af/ADMET-12-2460-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/7a5b8375e5a9/ADMET-12-2460-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/cdb452ccb267/ADMET-12-2460-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a93/11517520/a159130cef03/ADMET-12-2460-g005.jpg

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