Fung K P, Choy Y M, Chan T W, Lam W P, Lee C Y
Biochem Biophys Res Commun. 1986 Feb 13;134(3):1231-7. doi: 10.1016/0006-291x(86)90382-7.
The capacity of Ehrlich ascites tumour cells to take up 2-deoxy-D-glucose and to bind cytochalasin B varies adaptatively with the level of glucose in the plasma or culture medium. The effect of glucose is exerted directly on the cells and does not necessarily require the participation of hormones such as insulin, glucagon or corticosterone, although glucagon and the glucocorticoids, but not insulin, can also increase the number of glucose carrier molecules administered in vitro. Cycloheximide suppresses the acute inductive effect of glucose, suggesting that protein synthesis might be required for the increased transport activity.
艾氏腹水瘤细胞摄取2-脱氧-D-葡萄糖以及结合细胞松弛素B的能力会根据血浆或培养基中葡萄糖的水平适应性地变化。葡萄糖的作用直接施加于细胞，不一定需要胰岛素、胰高血糖素或皮质酮等激素的参与，尽管胰高血糖素和糖皮质激素（而非胰岛素）也能在体外增加所给予的葡萄糖载体分子的数量。放线菌酮抑制葡萄糖的急性诱导作用，这表明增加的转运活性可能需要蛋白质合成。
