[通过¹H-NMR对血清中肽降解的研究]
[Study of peptide degradation in the serum by 1H-NMR].
作者信息
Isakova O L, Sepetov N F, Bespalova Zh D, Bushuev V N, Vinogradov V A
出版信息
Bioorg Khim. 1986 Jan;12(1):106-11.
PMID:3947404
Abstract
Enzymatic degradation of hexapeptide Tyr-D-Ala-Gly-Phe-Leu-Arg in human serum has been investigated by 1H-NMR spectroscopy, and its pathways are suggested. Its final degradation products, tetra- and pentapeptide, are shown to be stable in human serum for several hours. The NMR spectroscopy application for pharmacokinetic studies is substantiated.
摘要
通过核磁共振氢谱（¹H-NMR）对人血清中六肽Tyr-D-Ala-Gly-Phe-Leu-Arg的酶促降解进行了研究，并推测了其降解途径。结果表明，其最终降解产物四肽和五肽在人血清中可稳定存在数小时。证实了核磁共振光谱在药代动力学研究中的应用。
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