Liu Jintao, Song Rong, Li Xuanxuan, Liu Li, Wei Ning, Yuan Jiajun, Yi Weizhuo, Pan Rubing, Cheng Jian, Zhang Xulai, Su Hong
Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230032, China.
Environ Health (Wash). 2024 Feb 27;2(5):290-300. doi: 10.1021/envhealth.3c00194. eCollection 2024 May 17.
Studies have indicated the different effects of PM components on human health. However, specific components that influence the severity of disease in schizophrenia patients and their underlying mechanisms remain unclear. Therefore, a repeated measures study for schizophrenia was constructed based on Anhui Mental Health Center. We collected information, including demographics and thyroid hormones (TH) levels, on repeat admissions of schizophrenia patients during 2017-2020, assessing their illness severity by positive and negative symptom scales (PANSS). Concentrations from the nearest component monitoring station in the 3 months before admission were assigned as the participant's exposure level. We assessed the effects of PM components individually and in combination on schizophrenia and explored the mediating role of THs. Results indicated that benzo[]pyrene, sulfate, nitrate, chloride, ammonia, cadmium, chromium, lead, selenium, and thallium exposure were associated with increased PANSS scores, with more significant results observed in males. Mixed exposure to PM components was found to be associated with increased PANSS scores and decreased free triiodothyronine (FT3). Mediation analysis suggested that the reduction in FT3 might mediate the association between the PM components and PANSS scores. The findings emphasize the impacts of PM components on schizophrenia and the potential value of focusing on changes in THs.
研究表明，细颗粒物（PM）成分对人类健康有不同影响。然而，影响精神分裂症患者疾病严重程度的具体成分及其潜在机制仍不清楚。因此，基于安徽精神卫生中心开展了一项针对精神分裂症的重复测量研究。我们收集了2017年至2020年期间精神分裂症患者再次入院时的信息，包括人口统计学资料和甲状腺激素（TH）水平，并用阳性和阴性症状量表（PANSS）评估他们的疾病严重程度。将入院前3个月内距离最近的成分监测站的浓度作为参与者的暴露水平。我们分别和综合评估了PM成分对精神分裂症的影响，并探讨了甲状腺激素的中介作用。结果表明，接触苯并[]芘、硫酸盐、硝酸盐、氯化物、氨、镉、铬、铅、硒和铊与PANSS评分升高有关，在男性中观察到的结果更显著。发现混合接触PM成分与PANSS评分升高和游离三碘甲状腺原氨酸（FT3）降低有关。中介分析表明，FT3的降低可能介导了PM成分与PANSS评分之间的关联。这些发现强调了PM成分对精神分裂症的影响以及关注甲状腺激素变化的潜在价值。
