颗粒物中多环芳烃、水溶性离子和金属与肝功能的关联：来自精神分裂症队列的证据。

Associations of polycyclic aromatic hydrocarbons, water-soluble ions and metals in PM with liver function: Evidence from schizophrenia cohort.

作者信息

Yi Weizhuo, Cheng Jun, Song Jian, Pan Rubing, Liang Yunfeng, Sun Xiaoni, Li Yuxuan, Wu Yudong, Yan Shuangshuang, Jin Xiaoyu, Mei Lu, Cheng Jian, Zhang Xulai, Su Hong

机构信息

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, China.

Anhui Mental Health Center, Hefei, Anhui, China.

出版信息

Sci Total Environ. 2023 Apr 10;868:161624. doi: 10.1016/j.scitotenv.2023.161624. Epub 2023 Jan 20.

DOI:10.1016/j.scitotenv.2023.161624

PMID:36681036

Abstract

BACKGROUND

Fine particulate matter (PM) was reported to impact liver function, but the roles of specific PM chemical components remained to be explored. Besides, severe liver dysfunction in schizophrenia patients deserves attention.

OBJECTIVE

To investigate the associations of short-term PM components with liver function in schizophrenia patients.

METHODS

A repeated-measures study based on schizophrenia cohort including 1023 visits (n = 446) was conducted during 2017-2020. Liver function was reflected by 10 indicators including liver enzymes, proteins and bilirubin et al. Monitoring data of PM and its components, including 16 polycyclic aromatic hydrocarbons (PAHs), 4 water-soluble ions and 10 metals were collected. Linear mixed effect and Bayesian kernel machine regression (BKMR) models were used to evaluate the single and combined effects of PM components (0-3 day) on liver function in schizophrenia patients.

RESULTS

Several PAHs were significantly associated with liver enzymes, while water-soluble ions and metal components had almost no association. Specifically, with per interquartile range (IQR) increased in Fluoranthene, levels of alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST) and gamma-glutamyl transpeptidase (GGT) increased by 2.06 %, 5.07 %, 4.94 % and 5.56 %, respectively. An IQR increases in Benzo[a]pyrene was significantly associated with 6.62 %, 3.67 % and 7.83 % increase in ALT, AST and GGT. Almost all PAHs, sulfate, nitrate, ammonium, Sb, Al, As, Pb, Mn and Tl were positively associated with albumin (ALB). Phenanthrene was associated with increased levels of direct bilirubin (DBIL) and total bilirubin (TBIL). The combined effects of significant PM components on ALP, GGT, ALB, globulin (GLOB), ratio of albumin to globulin (A/G), TBIL and total bile acid (TBA) were found by BKMR, respectively.

CONCLUSIONS

Findings highlight the short-term combined effects of PM components, especially PAHs, on liver function in schizophrenia patients, which contribute to the management of PM sources including combustion activities and traffic emissions as well as improving schizophrenia comorbidities.

摘要

背景

据报道，细颗粒物（PM）会影响肝功能，但特定PM化学成分的作用仍有待探索。此外，精神分裂症患者的严重肝功能障碍值得关注。

目的

研究精神分裂症患者短期PM成分与肝功能之间的关联。

方法

基于精神分裂症队列进行了一项重复测量研究，该队列在2017 - 2020年期间包括1023次就诊（n = 446）。肝功能由包括肝酶、蛋白质和胆红素等10项指标反映。收集了PM及其成分的监测数据，包括16种多环芳烃（PAHs）、4种水溶性离子和10种金属。采用线性混合效应和贝叶斯核机器回归（BKMR）模型评估PM成分（0 - 3天）对精神分裂症患者肝功能的单一和联合作用。

结果

几种PAHs与肝酶显著相关，而水溶性离子和金属成分几乎无关联。具体而言，荧蒽每增加一个四分位数间距（IQR），碱性磷酸酶（ALP）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和γ-谷氨酰转肽酶（GGT）水平分别升高2.06%、5.07%、4.94%和5.56%。苯并[a]芘增加一个IQR与ALT、AST和GGT分别显著升高6.62%、3.67%和7.83%相关。几乎所有PAHs、硫酸盐、硝酸盐、铵、锑、铝、砷、铅、锰和铊与白蛋白（ALB）呈正相关。菲与直接胆红素（DBIL）和总胆红素（TBIL）水平升高相关。BKMR分别发现了显著PM成分对ALP、GGT、ALB、球蛋白（GLOB）、白蛋白与球蛋白比值（A/G）、TBIL和总胆汁酸（TBA）的联合作用。