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嗜酸性食管炎的组织学表现：仅仅是一个神奇的数字？

Histological Presentation of Eosinophilic Esophagitis: Simply a Magic Number?

作者信息

Sterlacci William, Vieth Michael, Neurath Markus

机构信息

Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Klinikum Bayreuth, Bayreuth, Germany.

Medizinische Klinik 1 & Deutsches Zentrum Immuntherapie DZI, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

出版信息

Inflamm Intest Dis. 2024 Jul 29;9(1):220-228. doi: 10.1159/000540610. eCollection 2024 Jan-Dec.

DOI:10.1159/000540610
PMID:39474332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11521466/
Abstract

BACKGROUND

Eosinophilic esophagitis is an increasing condition in industrialized countries. The etiology is still somewhat unclear. It was thought that it can be part of eosinophilic gastroenteritis but nowadays seen as a separate entity and thus more often the esophagus is the only part of the gastrointestinal tract that is affected. Immunosuppressive and immunomodulatory treatment is available and can lead to symptom relief and remission.

SUMMARY AND KEY MESSAGES

In this article, the value and practicability of the histological criteria used for this disease are discussed. Also, the situation regarding the requirements for grading in clinical studies and routine settings is discussed.

摘要

背景

在工业化国家，嗜酸性食管炎的发病率呈上升趋势。其病因仍尚不完全清楚。过去认为它可能是嗜酸性胃肠炎的一部分，但如今被视为一种独立的疾病，因此食管往往是胃肠道中唯一受影响的部位。免疫抑制和免疫调节治疗是可行的，并且可以缓解症状并实现病情缓解。

总结与关键信息

在本文中，我们讨论了用于该疾病的组织学标准的价值和实用性。此外，还讨论了临床研究和常规环境中分级要求的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0e/11521466/4e71531a63c9/iid-2024-0009-0001-540610_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0e/11521466/f2db03dfa3be/iid-2024-0009-0001-540610_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0e/11521466/8cdcec76111f/iid-2024-0009-0001-540610_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0e/11521466/4e71531a63c9/iid-2024-0009-0001-540610_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0e/11521466/f2db03dfa3be/iid-2024-0009-0001-540610_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0e/11521466/8cdcec76111f/iid-2024-0009-0001-540610_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0e/11521466/4e71531a63c9/iid-2024-0009-0001-540610_F03.jpg

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1
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本文引用的文献

1
Monitoring Patients With Eosinophilic Esophagitis in Routine Clinical Practice - International Expert Recommendations.在常规临床实践中监测嗜酸性食管炎患者 - 国际专家建议。
Clin Gastroenterol Hepatol. 2023 Sep;21(10):2526-2533. doi: 10.1016/j.cgh.2022.12.018. Epub 2022 Dec 24.
2
Vonoprazan shows efficacy similar to that of proton pump inhibitors with respect to symptomatic, endoscopic, and histological responses in patients with eosinophilic esophagitis.Vonoprazan 在症状、内镜和组织学反应方面的疗效与质子泵抑制剂相似，适用于嗜酸细胞性食管炎患者。
Esophagus. 2021 Apr;18(2):372-379. doi: 10.1007/s10388-020-00783-0. Epub 2020 Sep 22.
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Eosinophilic Esophagitis Histology Remission Score: Significant Relations to Measures of Disease Activity and Symptoms.
嗜酸性粒细胞性食管炎组织学缓解评分：与疾病活动度和症状的测量指标有显著关系。
J Pediatr Gastroenterol Nutr. 2020 May;70(5):598-603. doi: 10.1097/MPG.0000000000002637.
4
Efficacy of Budesonide Orodispersible Tablets as Induction Therapy for Eosinophilic Esophagitis in a Randomized Placebo-Controlled Trial.布地奈德口腔崩解片作为嗜酸细胞性食管炎诱导治疗的疗效：一项随机安慰剂对照试验。
Gastroenterology. 2019 Jul;157(1):74-86.e15. doi: 10.1053/j.gastro.2019.03.025. Epub 2019 Mar 26.
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Eosinophilic esophagitis: Pathophysiology, diagnosis, and management.嗜酸性粒细胞性食管炎：病理生理学、诊断与管理
Arch Pediatr. 2019 Apr;26(3):182-190. doi: 10.1016/j.arcped.2019.02.005. Epub 2019 Mar 1.
6
A Conceptual Approach to Understanding Treatment Response in Eosinophilic Esophagitis.理解嗜酸性粒细胞性食管炎治疗反应的概念方法。
Clin Gastroenterol Hepatol. 2019 Oct;17(11):2149-2160. doi: 10.1016/j.cgh.2019.01.030. Epub 2019 Jan 30.
7
Long-Term Treatment of Eosinophilic Esophagitis With Swallowed Topical Corticosteroids: Development and Evaluation of a Therapeutic Concept.吞咽局部用皮质类固醇对嗜酸性食管炎的长期治疗：一种治疗理念的发展与评估
Am J Gastroenterol. 2017 Oct;112(10):1527-1535. doi: 10.1038/ajg.2017.202. Epub 2017 Jul 18.
8
Epithelial Thickness is a Marker of Gastroesophageal Reflux Disease.上皮厚度是胃食管反流病的标志物。
Clin Gastroenterol Hepatol. 2016 Nov;14(11):1544-1551.e1. doi: 10.1016/j.cgh.2016.06.018. Epub 2016 Jun 29.
9
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.新开发并经验证的嗜酸性食管炎组织学评分系统及其在疾病诊断和监测方面优于嗜酸性粒细胞峰值计数的证据。
Dis Esophagus. 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470.
10
Molecular diagnosis of eosinophilic esophagitis by gene expression profiling.通过基因表达谱分析进行嗜酸性粒细胞性食管炎的分子诊断。
Gastroenterology. 2013 Dec;145(6):1289-99. doi: 10.1053/j.gastro.2013.08.046. Epub 2013 Aug 23.