Agosta Viviana Teresa, D'Andria Ursoleo Jacopo, Bugo Samuele, Bottussi Alice, Losiggio Rosario, Monaco Fabrizio
Department of Anesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy.
Health Sci Rep. 2024 Oct 27;7(11):e70164. doi: 10.1002/hsr2.70164. eCollection 2024 Nov.
Over the past decades, the number of cardiac patients (e.g., with advanced heart failure or existing cardiovascular comorbidities that expose them to a heightened risk of acute cardiovascular decompensation) requiring noncardiac surgery is rising. For this patient population, potentially curative surgical treatments may be denied due to their prohibitive perioperative risk. Around 30% of patients undergoing general thoracic surgery experience cardiovascular complications of varying severity that may ultimately result in refractory heart failure and/or hemodynamic instability. In both these scenarios, perioperative implantation of temporary mechanical circulatory support (tMCS) may improve patient outcomes by both expanding preoperative surgical eligibility criteria and enabling safer management of unexpected periprocedural complications. This scoping review seeks to summarize the current existing evidence on the role of tMCS for cardiac assistance in thoracic surgery and provide a thorough overview.
We will perform a scoping review adhering to the Joanna Briggs Institute (JBI) methodology and the extension for Scoping Reviews of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis checklist (PRISMA). We will carry out a comprehensive search of several online databases to identify studies on the perioperative implantation of tMCS in patients undergoing thoracic surgery to provide cardiac assistance either due to their heightened preoperative cardiac risk (pre-emptive tMCS) or for acute cardiac failure due to inherent surgical complications (bail-out tMCS). Standardized forms will be employed to perform data charting and extraction.
Retrieved studies will be presented through a narrative synthesis following initial categorization, supplemented by descriptive statistical analyses of quantitative data if adequate inter-study homogeneity is observed and further complemented by figures and tables.
The planned scoping review aims to assess the safety and feasibility of perioperative implantation of tMCS in patients undergoing thoracic surgery either to mitigate their heightened cardiovascular risk or as a rescue strategy in the event of life-threatening surgical complications. It will identify knowledge gaps, offer direction for future research, and improve clinical practices within the field.
在过去几十年中,需要进行非心脏手术的心脏病患者(如患有晚期心力衰竭或存在心血管合并症,使其面临急性心血管失代偿风险增加)数量不断上升。对于这一患者群体,由于围手术期风险过高,可能无法接受具有潜在治愈效果的手术治疗。大约30%接受胸外科手术的患者会出现不同严重程度的心血管并发症,最终可能导致难治性心力衰竭和/或血流动力学不稳定。在这两种情况下,围手术期植入临时机械循环支持(tMCS)可能通过扩大术前手术适应证标准和实现对意外围手术期并发症的更安全管理来改善患者预后。本范围综述旨在总结当前关于tMCS在胸外科手术中提供心脏辅助作用的现有证据,并提供全面概述。
我们将按照乔安娜·布里格斯研究所(JBI)方法以及系统评价和Meta分析优先报告项目清单(PRISMA)的范围综述扩展版进行范围综述。我们将对多个在线数据库进行全面搜索,以识别关于在胸外科手术患者中围手术期植入tMCS以提供心脏辅助的研究,这些患者要么因术前心脏风险增加(预防性tMCS),要么因手术固有并发症导致急性心力衰竭(补救性tMCS)。将采用标准化表格进行数据图表绘制和提取。
检索到的研究将在初步分类后通过叙述性综合呈现,如果观察到足够的研究间同质性,将辅以定量数据的描述性统计分析,并进一步用图表补充。
计划进行的范围综述旨在评估围手术期在胸外科手术患者中植入tMCS以减轻其增加的心血管风险或作为危及生命的手术并发症的挽救策略的安全性和可行性。它将识别知识空白,为未来研究提供方向,并改善该领域的临床实践。