Medici Bianca, Caffari Eugenia, Salati Massimiliano, Spallanzani Andrea, Garajova Ingrid, Piacentini Federico, Dominici Massimo, Gelsomino Fabio
Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.
Medical Oncology Unit, University Hospital of Parma, Parma, Italy.
Case Rep Oncol. 2024 Oct 22;17(1):1208-1213. doi: 10.1159/000541337. eCollection 2024 Jan-Dec.
Spontaneous tumor regression is the volumetric reduction or complete disappearance of a primary tumor or metastatic sites (single or multiple) without the administration of treatments. This rare phenomenon occurs most commonly in certain types of neoplasms.
In this manuscript, we describe a spontaneous tumor regression in an adult patient followed at the Modena Cancer Center and affected by retroperitoneal inflammatory myofibroblastic tumor, an ultra-rare subtype of sarcoma. Finally, we will provide a concise review of the literature and try to explain the mechanisms underlying the tumor regression described in the clinical case.
The etiopathogenetic mechanisms for spontaneous tumor regression are not yet fully understood and likely involve a complex interplay among immunological mechanisms, growth factors, cytokines, and hormonal factors.
自发肿瘤消退是指在未进行治疗的情况下，原发性肿瘤或转移部位（单个或多个）的体积缩小或完全消失。这种罕见现象最常发生在某些类型的肿瘤中。
在本手稿中，我们描述了一名成年患者的自发肿瘤消退情况，该患者在摩德纳癌症中心接受随访，患有腹膜后炎性肌纤维母细胞瘤，这是一种极其罕见的肉瘤亚型。最后，我们将对文献进行简要综述，并尝试解释该临床病例中肿瘤消退的潜在机制。
自发肿瘤消退的病因发病机制尚未完全明确，可能涉及免疫机制、生长因子、细胞因子和激素因子之间的复杂相互作用。
