Domino L E, Domino S E, Stockstill M S
Br J Clin Pharmacol. 1986 Jan;21(1):71-4. doi: 10.1111/j.1365-2125.1986.tb02824.x.
The time course of toxicity in a 28 year old man following a 100 mg accidental overdose of clonidine hydrochloride is compared with the decline of plasma clonidine over 5 days. The concentration data were analyzed by nonlinear least squares regression, and fitted to a model which dissociated the blood pressure effects into pressor and depressor components. According to this analysis, there appeared to be two phases of toxicity over time--a hypertensive, and a hypotensive phase. The hypotensive and the hypertensive phases may result primarily through differential stimulation of central alpha 2-, alpha 1-, and vascular post-synaptic alpha 2-adrenoceptors as plasma concentrations fall.
一名28岁男性意外过量服用100毫克盐酸可乐定后的毒性时间进程，与5天内血浆可乐定的下降情况进行了比较。浓度数据通过非线性最小二乘法回归分析，并拟合到一个将血压效应分解为升压和降压成分的模型。根据该分析，随着时间推移，毒性似乎有两个阶段——高血压阶段和低血压阶段。随着血浆浓度下降，低血压阶段和高血压阶段可能主要是由于对中枢α2 -、α1 -和血管后突触α2 -肾上腺素能受体的不同刺激所致。
