Lilja M, Hakala M, Jounela A J
Ann Clin Res. 1984;16(1):10-2.
A hypertensive reaction is described in a 28-year-old woman with renal failure who took 30-70 clonidine tablets (150 micrograms each) with suicidal intent. She became increasingly drowsy. Her blood pressure on admission was 210/150 mmHg and gradually fell to 140/100 mmHg during the next 16 hours, at which time her plasma clonidine concentration was 4.7 ng/ml. This interesting hypertensive reaction was probably due to excessive stimulation of peripheral postsynaptic alpha-adrenoceptors.
一名28岁肾衰竭女性出于自杀意图服用了30至70片可乐定片剂（每片150微克），出现了高血压反应。她逐渐变得嗜睡。入院时她的血压为210/150 mmHg，在接下来的16小时内逐渐降至140/100 mmHg，此时她的血浆可乐定浓度为4.7 ng/ml。这种有趣的高血压反应可能是由于外周突触后α肾上腺素能受体受到过度刺激所致。
