Hogan M J, Wallin J D, Chu L C
Clin Pharmacol Ther. 1981 Dec;30(6):729-34. doi: 10.1038/clpt.1981.230.
Analysis of sequential plasma samples in 14 hypertensive subjects receiving their usual oral dose of clonidine (0.1 to 0.6 mg twice daily) indicated that clonidine plasma concentration increased for the first 2 hr and then decreased and stabilized over the next 12 hr. Percent fall in diastolic blood pressure, but not side effects, correlated well with plasma concentration. Our study indicates a potential role for plasma clonidine determination in the treatment of patients with hypertension. It also demonstrates that clonidine can probably be given at 12-hr intervals and be effective.
对14名接受常规口服可乐定剂量（每日两次，每次0.1至0.6毫克）的高血压患者的连续血浆样本分析表明，可乐定血浆浓度在最初2小时内升高，然后在接下来的12小时内下降并稳定。舒张压下降百分比与血浆浓度密切相关，但副作用与血浆浓度无关。我们的研究表明，测定血浆可乐定浓度在高血压患者治疗中具有潜在作用。研究还表明，可乐定可能每12小时给药一次且有效。
