Morphological changes in peripheral blood cells and skin in amiodarone-treated patients.
作者信息
Rappersberger K, Konrad K, Wieser E, Weber H, Wolff K
出版信息
Br J Dermatol. 1986 Feb;114(2):189-96. doi: 10.1111/j.1365-2133.1986.tb02797.x.
Abstract
Amiodarone, used in the treatment of cardiac arrhythmia, may lead to severe discolouration of sun-exposed skin. The lysosomal storage of a lipid-like material has been shown to be the morphological substrate for this cutaneous hyperpigmentation. Examination of peripheral white blood cells of amiodarone-treated patients disclosed identical lysosomal structures indicating that amiodarone treatment leads to a more generalized lysosomal storage of lipids and of amiodarone and its metabolites.
摘要
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