Ocrospoma Sebastian, Anzueto Antonio, Restrepo Marcos I
Division of Pulmonary Diseases & Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Section of Pulmonary & Critical Care Medicine, South Texas Veterans Health Care System, San Antonio, TX, USA.
Expert Rev Respir Med. 2024 Dec;18(12):975-989. doi: 10.1080/17476348.2024.2422961. Epub 2024 Nov 6.
Chronic Obstructive Pulmonary Disease (COPD) significantly predisposes the elderly to pneumonia, presenting a complex interplay of pulmonary dysfunction and infection risk.
This article reviews the substantial epidemiologic impact, elucidates the interlinked pathophysiology of COPD and pneumonia, and examines the microbial landscape shaping infection in these patients. It also evaluates management protocols and the multifaceted clinical challenges encountered during treatment.
Delving into the latest research, we underscore the criticality of preventive measures such as vaccination and present an integrated approach to managing Community-Acquired Pneumonia (CAP) in the COPD demographic. The review also proposes strategic directions for future investigations aimed at enhancing patient outcomes through a deeper understanding of the COPD-pneumonia nexus.
慢性阻塞性肺疾病(COPD)显著增加老年人患肺炎的风险,呈现出肺功能障碍与感染风险之间复杂的相互作用。
本文回顾了其重大的流行病学影响,阐明了COPD与肺炎相互关联的病理生理学,并研究了影响这些患者感染的微生物情况。还评估了管理方案以及治疗期间遇到的多方面临床挑战。
深入研究最新研究成果后,我们强调了诸如疫苗接种等预防措施的重要性,并提出了一种针对COPD人群管理社区获得性肺炎(CAP)的综合方法。该综述还为未来的研究提出了战略方向,旨在通过更深入地理解COPD与肺炎之间的联系来改善患者预后。