Mao Jiangfeng, Li Yafang, Lv Dong
Department of Respiratory Medicine, Shangyu People's Hospital of Shaoxing, Zhejiang 312300, China.
Department of Respiratory Medicine, Shangyu People's Hospital of Shaoxing, Zhejiang, China.
Ther Adv Respir Dis. 2025 Jan-Dec;19:17534666251363307. doi: 10.1177/17534666251363307. Epub 2025 Sep 9.
Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition associated with increased morbidity and mortality, particularly during respiratory infections such as influenza. The interaction between COPD and influenza is multifaceted, involving compromised immune responses, chronic inflammation, and impaired lung function. Influenza infection can exacerbate COPD, leading to acute exacerbations, hospitalizations, and higher mortality. This review examines the pathophysiological mechanisms underlying the exacerbation of COPD by influenza, evaluates its impact on patient outcomes, and explores the role of comorbidities in shaping disease severity. We also assess the effectiveness of influenza vaccination in preventing severe outcomes and discuss strategies to improve vaccination uptake among COPD patients. Current evidence highlights the importance of tailored prevention and management approaches, as well as the need for further research into biomarkers and optimal therapeutic strategies to mitigate the burden of influenza on COPD populations.
慢性阻塞性肺疾病（COPD）是一种常见的呼吸系统疾病，与发病率和死亡率增加相关，尤其是在流感等呼吸道感染期间。COPD与流感之间的相互作用是多方面的，涉及免疫反应受损、慢性炎症和肺功能受损。流感感染会加重COPD，导致急性加重、住院和更高的死亡率。本综述探讨了流感加重COPD的病理生理机制，评估其对患者预后的影响，并探讨合并症在影响疾病严重程度方面的作用。我们还评估了流感疫苗接种在预防严重后果方面的有效性，并讨论了提高COPD患者疫苗接种率的策略。目前的证据强调了量身定制的预防和管理方法的重要性，以及进一步研究生物标志物和最佳治疗策略以减轻流感对COPD人群负担的必要性。
