Kessel Klaus, Jääskeläinen Iiro, Hagberg Lars, Forsblom Erik, Järvinen Asko
Division of Infectious Diseases, Inflammation Center, Helsinki University Hospital, Helsinki, Finland.
Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Infect Dis (Lond). 2025 Mar;57(3):278-283. doi: 10.1080/23744235.2024.2420238. Epub 2024 Oct 30.
Alcoholism increases the risk of skin and skin structure infections (SSSIs). Furthermore, in complicated SSSIs (cSSSIs) alcoholism is associated with delayed treatment response and a higher risk of blood culture positivity, suggesting poor outcomes. In pneumonia and bacteremia alcoholism is linked with higher mortality, longer hospital treatment and more ICU treatment.
We conducted a population-based retrospective cohort study including all cases of complicated skin and skin structure infections ( = 460) treated in Gothenburg, Sweden and Helsinki, Finland from 2008 - 2011. Patients were stratified as alcoholics (9%) and non-alcoholics (91%) and patient and disease factors, treatment, and outcomes were compared.
Alcoholics were comparatively younger and more often male, with more liver diseases. We observed higher rates of bacteraemia, intensive care unit admission, surgical intervention, and clinical failure in alcoholics. Alcoholism was associated with longer length of stay and more interdepartmental transfers. We did not observe differences in infection type or time from symptom onset to diagnosis. Mortality was low and equivalent in alcoholics and non-alcoholics.
Alcoholism is associated with increased cSSSI disease severity and resource utilisation.
酗酒会增加皮肤及皮肤结构感染（SSSI）的风险。此外，在复杂性皮肤及皮肤结构感染（cSSSI）中，酗酒与治疗反应延迟及血培养阳性风险较高相关，提示预后较差。在肺炎和菌血症中，酗酒与较高的死亡率、更长的住院治疗时间及更多的重症监护病房（ICU）治疗相关。
我们进行了一项基于人群的回顾性队列研究，纳入了2008年至2011年在瑞典哥德堡和芬兰赫尔辛基接受治疗的所有复杂性皮肤及皮肤结构感染病例（n = 460）。将患者分为酗酒者（9%）和非酗酒者（91%），并比较患者和疾病因素、治疗及预后。
酗酒者相对更年轻，男性比例更高，患有更多肝脏疾病。我们观察到酗酒者的菌血症发生率、重症监护病房入住率、手术干预率及临床失败率更高。酗酒与更长的住院时间及更多的科室间转诊相关。我们未观察到感染类型或从症状出现到诊断的时间存在差异。酗酒者和非酗酒者的死亡率均较低且相当。
酗酒与cSSSI疾病严重程度增加及资源利用增加相关。
