Wróblewska Joanna, Długosz Anna, Czarnecki Damian, Tomaszewicz Wioletta, Błaszak Błażej, Szulc Joanna, Wróblewska Weronika
Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St., 85-092 Bydgoszcz, Poland.
Department of Food Industry Technology and Engineering, Faculty of Chemical Technology and Engineering, Bydgoszcz University of Science and Technology, 3 Seminaryjna St., 85-326 Bydgoszcz, Poland.
Molecules. 2025 Jul 25;30(15):3111. doi: 10.3390/molecules30153111.
Alcohol dependency is a complex and chronic condition that negatively impacts multiple organ systems, including the skin. A key pathological factor in this process is oxidative stress, leading to progressive cellular damage, chronic inflammation, and accelerated cutaneous aging. Alcohol metabolism generates reactive oxygen species (ROS), which overwhelm endogenous antioxidant defenses and contribute to a range of skin alterations, including nonspecific changes such as xerosis, erythema, and wrinkle formation, as well as inflammatory and neoplastic skin disorders. Additionally, alcohol-induced alterations of the skin microbiome may further exacerbate skin barrier dysfunction and inflammatory responses. This review explores the biochemical mechanisms and skin microbiome alterations linking alcohol-induced oxidative stress to skin damage and disease. Furthermore, it evaluates the therapeutic potential of antioxidant-based interventions, both natural and synthetic. Antioxidants may offer protective and regenerative effects by scavenging free radicals, modulating inflammatory responses, and enhancing skin barrier function. The paper aims to provide a comprehensive overview of the molecular and microbial interplay between alcohol, oxidative stress, and skin health, while identifying future directions for targeted antioxidant therapy in individuals with alcohol dependency.
酒精依赖是一种复杂的慢性疾病，会对包括皮肤在内的多个器官系统产生负面影响。这一过程中的一个关键病理因素是氧化应激，会导致细胞进行性损伤、慢性炎症和皮肤加速老化。酒精代谢产生活性氧（ROS），其超过内源性抗氧化防御能力，并导致一系列皮肤改变，包括皮肤干燥、红斑和皱纹形成等非特异性变化，以及炎症性和肿瘤性皮肤疾病。此外，酒精引起的皮肤微生物群改变可能会进一步加剧皮肤屏障功能障碍和炎症反应。本综述探讨了将酒精诱导的氧化应激与皮肤损伤和疾病联系起来的生化机制以及皮肤微生物群的改变。此外，它评估了天然和合成的基于抗氧化剂的干预措施的治疗潜力。抗氧化剂可以通过清除自由基、调节炎症反应和增强皮肤屏障功能来提供保护和再生作用。本文旨在全面概述酒精、氧化应激和皮肤健康之间的分子和微生物相互作用，同时确定针对酒精依赖个体的靶向抗氧化治疗的未来方向。
