Ferrant A, Rodhain J, Leners N, Cogneau M, Verwilghen R L, Michaux J L, Sokal G
Br J Haematol. 1986 Feb;62(2):247-55. doi: 10.1111/j.1365-2141.1986.tb02928.x.
Quantitative 52Fe scans were performed in 180 patients. Expansion of bone marrow was observed in 70. This bone marrow expansion was a nearly constant feature in haemolytic anaemia and in sideroblastic anaemia. It occurred in a third of the patients with myelofibrosis. In patients with polycythaemia rubra vera, expansion was noticed in only two out of seven. Erythropoiesis in expansion areas occurred despite persistence of fat in the iliac crest bone marrow biopsy. It could exist with a slight increase in erythropoiesis and might develop only after a long period of erythropoietic stimulation. Increased marrow activity can take place without erythropoietic expansion in long bones. The fraction of iron uptake in expansion areas did not exceed a third of total marrow iron uptake. With increasing erythropoiesis, the increase in iron uptake in expansion areas was less marked than the increase in the central areas. Erythropoiesis in expansion areas was usually not of major quantitative importance but could nevertheless reach the erythropoiesis of a normal adult.
对180例患者进行了52铁定量扫描。70例观察到骨髓扩张。这种骨髓扩张在溶血性贫血和铁粒幼细胞贫血中几乎是一个恒定特征。三分之一的骨髓纤维化患者出现这种情况。在真性红细胞增多症患者中，7例中只有2例发现有扩张。尽管髂嵴骨髓活检中仍存在脂肪，但扩张区域仍有红细胞生成。它可能伴随着红细胞生成的轻微增加而存在，并且可能仅在长期的红细胞生成刺激后才会发展。长骨中骨髓活性增加可在无红细胞生成扩张的情况下发生。扩张区域的铁摄取分数不超过骨髓总铁摄取量的三分之一。随着红细胞生成的增加，扩张区域铁摄取的增加不如中心区域明显。扩张区域的红细胞生成通常在数量上不具有主要重要性，但仍可达到正常成年人的红细胞生成水平。
