School of Mechanical Engineering, Dalian Jiao Tong University, Dalian 116028, China.
Department of Spine Surgery, Dalian Second People's Hospital, Dalian 116011, China.
ACS Biomater Sci Eng. 2024 Nov 11;10(11):6954-6963. doi: 10.1021/acsbiomaterials.4c00268. Epub 2024 Oct 30.
Porous implant prostheses can effectively reduce the stress shielding effect. Still, the single elastic modulus prosthesis cannot adapt to the individual skeletal variability, so it is necessary to optimize the structural parameters of the prosthesis to overcome the individual variability. In this regard, this study analyzes the law of structural parameters and mechanical properties after selecting the type of porous structure (diamond structure). It proposes the optimization method of the structural parameters on this basis. First, the functional relationship equations between the unit mass of the porous implant prosthesis, the elastic modulus of the porous implant prosthesis, and the structural parameters were established respectively. Second, the support rod length and radius of the porous implant prosthesis are optimized by a genetic algorithm to form the optimization design method of the porous implant prosthesis. Finally, the feasibility and effectiveness of the optimized design of the porosity implanted prosthesis were verified by animal experiments, and the optimized implanted prosthesis with optimized structural parameters increased bone growth by 20-30% compared to the control group in the animal body. The proposed method provides a theoretical basis and technical support for the rehabilitation of patients and the production of prostheses by physicians.
多孔植入式假体可以有效地降低应力遮挡效应。然而，单一弹性模量的假体不能适应个体骨骼的可变性，因此有必要优化假体的结构参数以克服个体可变性。在这方面，本研究在选择多孔结构类型（金刚石结构）后分析了结构参数和力学性能的变化规律。在此基础上提出了结构参数的优化方法。首先，分别建立多孔植入式假体的单位质量、多孔植入式假体的弹性模量与结构参数之间的函数关系方程。其次，通过遗传算法对多孔植入式假体的支撑杆长度和半径进行优化，形成多孔植入式假体的优化设计方法。最后，通过动物实验验证了多孔植入式假体优化设计的可行性和有效性，与对照组相比，具有优化结构参数的优化植入式假体在动物体内增加了 20-30%的骨生长。该方法为患者康复和医生生产假体提供了理论依据和技术支持。
