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氯氮平用于一名老年帕金森病患者的精神病治疗:噩梦变为福祉。

Clozapine for Parkinson's disease psychosis in a septuagenarian: a nightmare turned into bliss.

作者信息

Makani Janki, Kumar Anand, Hussain Ibrahim, Kumar Niraj, Joshi Deepika

机构信息

Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.

Department of Neurology, AIIMS, Bibinagar, 508126, Telangana, India.

出版信息

Neurol Sci. 2025 Mar;46(3):1415-1417. doi: 10.1007/s10072-024-07852-7. Epub 2024 Oct 30.

Abstract

Parkinson's disease psychosis, characterized by confusion, visual hallucinations, and delusions is a nightmare for the patients and caregivers. Classic neuroleptics aggravate the motor symptoms, hence the need for an effective atypical antipsychotic. Currently Pimavanserin is the only approved drug for Parkinson's disease psychosis (PDP), however it is not readily available. Clozapine with its excellent anti psychotic profile, without worsening of motor features, cost effectiveness and easy availability transcends all boundaries in improving the Quality of life in PD patients with psychosis. We describe an elderly patient with PDP with an excellent response to low dose clozapine.

摘要

帕金森病精神病,其特征为意识模糊、视幻觉和妄想,对患者及护理人员来说犹如噩梦。经典抗精神病药会加重运动症状,因此需要一种有效的非典型抗精神病药。目前,匹莫范色林是唯一获批用于治疗帕金森病精神病(PDP)的药物,但它并不容易获得。氯氮平具有出色的抗精神病特性,不会使运动功能恶化,具有成本效益且容易获取,在改善患有精神病的帕金森病患者的生活质量方面毫无局限。我们描述了一名患有帕金森病精神病的老年患者,其对低剂量氯氮平有极佳反应。

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