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Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans.

作者信息

Fischer Ian C, Na Peter J, Nagamatsu Sheila T, Jeste Dilip V, Cabrera-Mendoza Brenda, Montalvo-Ortiz Janitza L, Krystal John H, Polimanti Renato, Gelernter Joel, Pietrzak Robert H

机构信息

US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven.

Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.

出版信息

JAMA Psychiatry. 2024 Dec 1;81(12):1276-1277. doi: 10.1001/jamapsychiatry.2024.3403.

DOI:10.1001/jamapsychiatry.2024.3403
PMID:39476130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11581715/
Abstract
摘要

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本文引用的文献

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Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans.美国退伍军人创伤后应激障碍症状与GrimAge（一种死亡风险的表观遗传标志物）的关联
J Clin Psychiatry. 2022 Jul 6;83(4):21br14309. doi: 10.4088/JCP.21br14309.
2
Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress.创伤后应激障碍症状严重程度的表观基因组范围荟萃分析表明，免疫系统和氧化应激相关基因中的 DNA 甲基化变化与 3 个军事队列有关。
Mol Psychiatry. 2022 Mar;27(3):1720-1728. doi: 10.1038/s41380-021-01398-2. Epub 2022 Jan 7.
3
Testing a tailored weight management program for veterans with PTSD: The MOVE! + UP randomized controlled trial.针对患有 PTSD 的退伍军人进行定制化体重管理项目的测试：MOVE！+ UP 随机对照试验。
Contemp Clin Trials. 2021 Aug;107:106487. doi: 10.1016/j.cct.2021.106487. Epub 2021 Jun 16.
4
A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration.系统综述与表观遗传时钟加速相关的生物、社会和环境因素。
Ageing Res Rev. 2021 Aug;69:101348. doi: 10.1016/j.arr.2021.101348. Epub 2021 Apr 28.
5
Associations of Body Composition and Physical Activity Level With Multiple Measures of Epigenetic Age Acceleration.体成分和身体活动水平与多种表观遗传年龄加速指标的关联。
Am J Epidemiol. 2021 Jun 1;190(6):984-993. doi: 10.1093/aje/kwaa251.
6
DNA methylation GrimAge strongly predicts lifespan and healthspan.DNA甲基化GrimAge能有力地预测寿命和健康跨度。
Aging (Albany NY). 2019 Jan 21;11(2):303-327. doi: 10.18632/aging.101684.