Wolff M, Morceau S, Folkard R, Martin-Cortecero J, Groh A
CNRS, INCIA, UMR 5287, Bordeaux, France; University of Bordeaux, INCIA, UMR 5287, Bordeaux, France.
CNRS, INCIA, UMR 5287, Bordeaux, France; University of Bordeaux, INCIA, UMR 5287, Bordeaux, France.
Neurosci Biobehav Rev. 2021 Jan;120:222-235. doi: 10.1016/j.neubiorev.2020.11.013. Epub 2020 Nov 24.
The ability to adapt to dynamic environments requires tracking multiple signals with variable sensory salience and fluctuating behavioral relevance. This complex process requires integrative crosstalk between sensory and cognitive brain circuits. Functional interactions between cortical and thalamic regions are now considered essential for both sensory perception and cognition but a clear account of the functional link between sensory and cognitive circuits is currently lacking. This review aims to document how thalamic nuclei may effectively act as a bridge allowing to fuse perceptual and cognitive events into meaningful experiences. After highlighting key aspects of thalamocortical circuits such as the classic first-order/higher-order dichotomy, we consider the role of the thalamic reticular nucleus from directed attention to cognition. We next summarize research relying on Pavlovian learning paradigms, showing that both first-order and higher-order thalamic nuclei contribute to associative learning. Finally, we propose that modulator inputs reaching all thalamic nuclei may be critical for integrative purposes when environmental signals are computed. Altogether, the thalamus appears as the bridge linking perception, cognition and possibly affect.
适应动态环境的能力需要追踪具有可变感官显著性和波动行为相关性的多种信号。这一复杂过程需要感觉和认知脑回路之间的整合性相互作用。皮层和丘脑区域之间的功能相互作用现在被认为对感觉知觉和认知都至关重要，但目前尚缺乏对感觉和认知回路之间功能联系的清晰描述。本综述旨在阐述丘脑核如何有效地充当一座桥梁，将感知和认知事件融合为有意义的体验。在强调丘脑皮质回路的关键方面（如经典的一级/高级二分法）之后，我们考虑丘脑网状核从定向注意到认知的作用。接下来，我们总结了依赖巴甫洛夫学习范式的研究，表明一级和高级丘脑核都对联想学习有贡献。最后，我们提出，当计算环境信号时，到达所有丘脑核的调制输入可能对整合目的至关重要。总之，丘脑似乎是连接感知、认知以及可能的情感的桥梁。
