Li Yuxin, Farhan Muhammad Haris Raza, Yang Xiaohan, Guo Ying, Sui Yuxin, Chu Jinhua, Huang Lingli, Cheng Guyue
National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, Hubei 430070, PR China; MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
Int J Biol Macromol. 2024 Dec;282(Pt 5):136827. doi: 10.1016/j.ijbiomac.2024.136827. Epub 2024 Oct 28.
Bacterial vaccines play a crucial role in combating bacterial infectious diseases. Apart from the prevention of disease, bacterial vaccines also help to reduce the mortality rates in infected populations. Advancements in vaccine development technologies have addressed the constraints of traditional vaccine design, providing novel approaches for the development of next-generation vaccines. Advancements in reverse vaccinology, bioinformatics, and comparative proteomics have opened horizons in vaccine development. Specifically, the use of protein structural data in crafting multi-epitope vaccines (MEVs) to target pathogens has become an important research focus in vaccinology. In this review, we focused on describing the methodologies and tools for epitope vaccine development, along with recent progress in this field. Moreover, this article also discusses the challenges in epitope vaccine development, providing insights for the future development of bacterial multi-epitope genetically engineered vaccines.
细菌疫苗在对抗细菌感染性疾病中发挥着关键作用。除了预防疾病外，细菌疫苗还有助于降低感染人群的死亡率。疫苗开发技术的进步克服了传统疫苗设计的局限性，为下一代疫苗的开发提供了新方法。反向疫苗学、生物信息学和比较蛋白质组学的进展为疫苗开发开辟了新视野。具体而言，利用蛋白质结构数据设计针对病原体的多表位疫苗（MEV）已成为疫苗学的一个重要研究重点。在本综述中，我们着重描述了表位疫苗开发的方法和工具，以及该领域的最新进展。此外，本文还讨论了表位疫苗开发中的挑战，为细菌多表位基因工程疫苗的未来发展提供见解。
