Kupfer D J, Reynolds C F, Ulrich R F, Grochocinski V J
Biol Psychiatry. 1986 Feb;21(2):189-200. doi: 10.1016/0006-3223(86)90146-0.
A comparison of electroencephalographic sleep measures between young and middle-aged groups of depressed inpatients was conducted with specific interest in the application of automated measures of REM and delta wave sleep. Aside from the expected differences in sleep continuity, increased Stage 1 percent, decreased Stage 2 percent, and decreased REM latency in the middle-aged depressives as compared to the younger depressives, distinct findings from automated analyses were noted in the distribution of REM and delta sleep throughout the night. Although the younger depressed patients showed increased numbers of delta waves, the middle-aged depressives showed greater average REM count. Such changes were more pronounced in the first third of the night. Finally, in the middle-aged depressives, little statistical relationship between manual measures of slow-wave sleep and automated measures of delta sleep was found.
对年轻和中年抑郁症住院患者的脑电图睡眠指标进行了比较，特别关注快速眼动（REM）睡眠和慢波睡眠自动测量方法的应用。除了预期的睡眠连续性差异外，与年轻抑郁症患者相比，中年抑郁症患者的第1阶段睡眠百分比增加、第2阶段睡眠百分比降低以及REM潜伏期缩短，夜间REM睡眠和慢波睡眠分布的自动分析有明显发现。虽然年轻抑郁症患者的慢波数量增加，但中年抑郁症患者的平均REM计数更高。这种变化在夜间的前三分之一更为明显。最后，在中年抑郁症患者中，慢波睡眠的人工测量与慢波睡眠的自动测量之间几乎没有统计学关系。
