Nasrallah H A, Andreasen N C, Coffman J A, Olson S C, Dunn V D, Ehrhardt J C, Chapman S M
Biol Psychiatry. 1986 Mar;21(3):274-82. doi: 10.1016/0006-3223(86)90048-x.
Two previous postmortem studies reported an increased thickness of the corpus callosum in schizophrenic patients compared to psychiatric controls. We report an in vivo study of the corpus callosum in schizophrenic patients (n = 38) and healthy controls (n = 41) using magnetic resonance (MR) brain imaging. A significant increase in mean callosal thickness was found in the middle and anterior, but not the posterior, parts of the callosal body. However, when the patients and controls were compared by gender and handedness, schizophrenic men were found not to differ from control men in callosal thickness, regardless of handedness, whereas schizophrenic women were found to have a highly significant increase in callosal middle and anterior thickness compared to control women. The data suggest that increased callosal thickness in schizophrenia is gender related, a factor that is not considered by postmortem studies. The implications of increased callosal dimensions in female schizophrenics are discussed.
两项先前的尸检研究报告称，与精神科对照相比，精神分裂症患者的胼胝体厚度增加。我们报告了一项对38名精神分裂症患者和41名健康对照者进行的活体胼胝体研究，采用磁共振（MR）脑成像技术。在胼胝体中部和前部发现平均胼胝体厚度显著增加，但后部未发现。然而，当按性别和利手对患者和对照进行比较时，发现精神分裂症男性无论利手如何，其胼胝体厚度与对照男性无差异，而精神分裂症女性与对照女性相比，胼胝体中部和前部厚度有极显著增加。数据表明，精神分裂症患者胼胝体厚度增加与性别有关，这是尸检研究未考虑的一个因素。本文讨论了女性精神分裂症患者胼胝体尺寸增加的意义。
