Firat A, Tascioglu A B, Demiryurek M D, Saygi S, Karli Oguz K, Tezer F I, Hayran M
Department of Anatomy, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, 06100, Turkey,
Surg Radiol Anat. 2014 Jan;36(1):47-54. doi: 10.1007/s00276-013-1144-y. Epub 2013 Jun 15.
The purpose of the study was to evaluate the effects of mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) on corpus callosum (CC) morphometry in large and pathologically proven MTLE-HS patients.
We measured certain CC dimensions in 103 patients and 33 healthy controls using in vivo magnetic resonance imaging. In particular, we compared the two groups in relation to the clinical (localization of the HS, duration of epilepsy, frequency of seizures and length of seizures) and demographical (age, gender, handedness) features. Students' t test, two-way ANOVA and Spearman test were used for statistical analysis.
There was no significant difference between CC morphometry with respect to age and handedness among patients. The differences between the genders, however, were significant favouring longer diameters in males. We found significant decrease in the dimensions of the genu, body, isthmus and splenium of the CC in the MTLE-HS group, but there was no reduction in the size of the rostrum.
This general reduction in the size of the CC except for the rostrum was thought to be the result of cortical atrophy secondary to the disease. Concerning the preserved rostral part of the CC, it was thought that the fibers of the frontal lobe pass through different pathways than the tracts in the rostrum.
本研究旨在评估患有海马硬化的内侧颞叶癫痫（MTLE-HS）对大量经病理证实的MTLE-HS患者胼胝体（CC）形态学的影响。
我们使用活体磁共振成像测量了103例患者和33名健康对照者的某些CC维度。具体而言，我们比较了两组在临床（海马硬化的定位、癫痫持续时间、癫痫发作频率和发作时长）和人口统计学（年龄、性别、利手）特征方面的差异。采用学生t检验、双向方差分析和Spearman检验进行统计分析。
患者之间CC形态学在年龄和利手方面无显著差异。然而，性别之间存在显著差异，男性的直径更长。我们发现MTLE-HS组中CC的膝部、体部、峡部和压部尺寸显著减小，但嘴部大小没有减小。
除嘴部外，CC大小的普遍减小被认为是该疾病继发皮质萎缩所致。关于CC保留的嘴部部分，人们认为额叶纤维通过的途径与嘴部的束不同。
