Woodruff P W, McManus I C, David A S
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
J Neurol Neurosurg Psychiatry. 1995 Apr;58(4):457-61. doi: 10.1136/jnnp.58.4.457.
Studies with MRI have shown differences in corpus callosum size between schizophrenic patients and controls. Most have found that the corpus callosum is smaller in schizophrenic patients, but in only a minority was this finding statistically significant, perhaps due to small sample sizes. Therefore a meta-analysis of 11 published studies of corpus callosum morphology in schizophrenia was conducted to ascertain whether there was a significant difference in corpus callosum size between schizophrenic patients and normal controls. These studies combined comprised 313 patients and 281 controls. Measures of corpus callosum midsagittal area, length, and corpus callosum area:brain area ratio were used in the meta-analysis. There was overall a statistically significant reduction in corpus callosum area in schizophrenic patients compared with controls (P < 0.02). Differences between patients and controls in measures of corpus callosum: brain area and corpus callosum length were not statistically significant. Age and corpus callosum area were related in both patients and controls. The influences on the corpus callosum of overall alterations of brain size, sex, handedness, and psychiatric illness in general remains to be determined.
磁共振成像研究显示，精神分裂症患者与对照组在胼胝体大小上存在差异。大多数研究发现，精神分裂症患者的胼胝体较小，但只有少数研究的这一发现具有统计学意义，这可能是由于样本量较小。因此，对11项已发表的关于精神分裂症胼胝体形态学的研究进行了荟萃分析，以确定精神分裂症患者与正常对照组在胼胝体大小上是否存在显著差异。这些研究总共纳入了313例患者和281例对照。荟萃分析中使用了胼胝体矢状面中部面积、长度以及胼胝体面积与脑面积之比等测量指标。总体而言，与对照组相比，精神分裂症患者的胼胝体面积在统计学上有显著减小（P < 0.02）。患者与对照组在胼胝体面积与脑面积之比以及胼胝体长度测量指标上的差异无统计学意义。患者和对照组的年龄与胼胝体面积均相关。脑大小、性别、利手以及一般精神疾病的总体改变对胼胝体的影响仍有待确定。
