Dovgiĭ A I, Andrianov N V, Archakov A I
Biull Eksp Biol Med. 1986 Feb;101(2):167-70.
The effect of liver monooxygenase system substrates upon the rate of cytochrome P-450 isoform degradation was investigated by measuring the half-life of liver microsomal proteins in C57BL/6 mice injected with phenobarbital and then 24 hours later with aminopyrine every 6 hours. The rate of phenobarbital-induced degradation of cytochrome P-450 isoform (mol weight 56000 daltons) was shown to be increased two-fold.
通过测量注射苯巴比妥后每6小时再注射氨基比林的C57BL/6小鼠肝脏微粒体蛋白的半衰期，研究了肝脏单加氧酶系统底物对细胞色素P-450同工型降解速率的影响。结果显示，苯巴比妥诱导的细胞色素P-450同工型（分子量56000道尔顿）的降解速率增加了两倍。
