Shumway Julia, Ellis Jill, Stephens Alice, De Stavola Bianca Lucia, Gilbert Ruth, Zylbersztejn Ania
Population, Policy and Practice, University College London Great Ormond Street Institute of Child Health, London, UK
East London NHS Foundation Trust, London, UK.
Arch Dis Child. 2025 Feb 19;110(3):221-227. doi: 10.1136/archdischild-2024-327532.
The objective is to describe age-specific cumulative incidence for hospital-recorded indicators of chronic health conditions (CHCs) in children with Down syndrome (DS) compared with children without DS.
National birth cohort using hospital admission and death records.
National Health Service (NHS)-funded hospitals in England.
Liveborn, singleton infants born in NHS-funded hospitals between 2003 and 2019.
Cumulative incidence of nine categories of hospital-recorded CHCs, multimorbidity and mortality.
We identified 10 621 infants with DS among 9 631 646 liveborn, singleton infants (0.11%). Among children with DS, the cumulative incidence for any indicated CHC was 90.1% by age 16, as compared with 21.2% of children without DS. By age 16, a third of children (33.1%) with DS had CHCs affecting four or more body systems; only 6.0% of children without DS had CHCs indicated in more than one body system. The most common CHCs in children with DS were severe congenital heart defects, indicated in 57.2% (0.8% in children without DS). The estimated HR for mortality up to age 16 comparing children with versus without DS was 15.26 (95% CI: 14.15, 16.45).
Children with DS had a higher cumulative incidence for CHCs in each body system category and subcategory, at all ages, than children without DS. Multimorbidity and mortality were higher among children with DS. Administrative data can be used to examine the health needs and healthcare use of children with DS throughout childhood and adolescence.
描述唐氏综合征（DS）患儿与非DS患儿相比，医院记录的慢性健康状况（CHC）指标的年龄特异性累积发病率。
利用医院入院和死亡记录的全国出生队列研究。
英国国家医疗服务体系（NHS）资助的医院。
2003年至2019年在NHS资助医院出生的活产单胎婴儿。
九类医院记录的CHC、多种疾病并存和死亡率的累积发病率。
在9631646例活产单胎婴儿中，我们识别出10621例DS患儿（0.11%）。DS患儿中，任何指定CHC的累积发病率在16岁时为90.1%，而非DS患儿为21.2%。到16岁时，三分之一（33.1%）的DS患儿患有影响四个或更多身体系统的CHC；非DS患儿中只有6.0%的CHC涉及多个身体系统。DS患儿中最常见的CHC是严重先天性心脏缺陷，发病率为57.2%（非DS患儿为0.8%）。16岁前DS患儿与非DS患儿相比的估计死亡风险比为15.26（95%CI：14.15，16.45）。
DS患儿在各年龄阶段，每个身体系统类别和亚类中CHC的累积发病率均高于非DS患儿。DS患儿的多种疾病并存情况和死亡率更高。行政数据可用于研究DS患儿在整个儿童期和青春期的健康需求及医疗保健使用情况。
