Boukhris Samia Alaoui, Khadir Mounia El, Karim Safae, Souho Tiatou, Benajah Dafr-Allah, Ibrahimi Sidi Adil, Chbani Laila, Abkari Mohamed El, Bennani Bahia
URL-CNRST No. 15, Laboratory of Human Pathology Biomedicine and Environment, Faculty of Medicine, Pharmacy and Dentistry of Fez (FMPDF), Sidi Mohammed Ben Abdellah University (USMBA), Morocco.
The Higher Institute of Nursing Professions and Health Techniques (ISPITS), Morocco.
Jpn J Infect Dis. 2025 Mar 21;78(2):99-105. doi: 10.7883/yoken.JJID.2024.147. Epub 2024 Oct 31.
Helicobacter pylori, Epstein-Barr virus (EBV), and human papillomavirus (HPV) are three pathogens associated with various human cancers. This study aimed to investigate the role of these pathogens in gastric cancer in a Moroccan population. A retrospective study was conducted with participants attending the Gastroenterology Department of Hassan II University Hospital in Fez. In total, 279 participants were enrolled in this study. Helicobacter pylori, EBV, and HPV were detected and genotyped using polymerase chain reaction. Significant associations have been established between H. pylori and EBV and gastric cancer. A total of 93.4% and 43.3% of gastric cancer cases were related to H. pylori and EBV, respectively (P ≤ 0.01). Helicobacter pylori-EBV co-infection was responsible for 31.6% of gastric cancer cases (P < 0.01). Correlation between pathogen genotypes and gastric cancer showed that 54.6% of gastric cancer EBV positive cases had a 30 bp deletion in the LMP1 gene, whereas 16% of gastric cancer cases had high-risk HPV genotypes (P = 0.21). These results highlight the possible role of co-infection in gastric cancer development.
幽门螺杆菌、爱泼斯坦-巴尔病毒（EBV）和人乳头瘤病毒（HPV）是三种与多种人类癌症相关的病原体。本研究旨在调查这些病原体在摩洛哥人群胃癌中的作用。对在非斯哈桑二世大学医院胃肠病科就诊的参与者进行了一项回顾性研究。本研究共纳入279名参与者。使用聚合酶链反应检测幽门螺杆菌、EBV和HPV并进行基因分型。已确定幽门螺杆菌和EBV与胃癌之间存在显著关联。分别有93.4%和43.3%的胃癌病例与幽门螺杆菌和EBV有关（P≤0.01）。幽门螺杆菌-EBV合并感染导致31.6%的胃癌病例（P<0.01）。病原体基因型与胃癌之间的相关性表明，54.6%的EBV阳性胃癌病例LMP1基因有30 bp缺失，而16%的胃癌病例有高危HPV基因型（P=0.21）。这些结果突出了合并感染在胃癌发生中的可能作用。
