氟化亚锡改性唾液薄膜对牙侵蚀的预防作用。
The preventive effect of silver diamine fluoride-modified salivary pellicle on dental erosion.
作者信息
Chawhuaveang Darren Dhananthat, Lam Walter Yu Hang, Chu Chun Hung, Yu Ollie Yiru
机构信息
Cariology, Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Cariology, Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
出版信息
Dent Mater. 2025 Jan;41(1):58-69. doi: 10.1016/j.dental.2024.10.014. Epub 2024 Oct 29.
OBJECTIVE
To investigate the preventive effect of silver diamine fluoride (SDF) modified salivary pellicle (SP) against dental erosion.
METHODS
Enamel and dentin blocks allocated into 4 groups (n = 30 each). Blocks in Group SDF+SP were treated with SDF and SP. Blocks in Group SDF were treated with SDF. Blocks in Group DW+SP were treated with deionized water (DW) and SP. Blocks in Group DW were treated with DW. The blocks were subjected to an erosive challenge at pH 3.2 for 2 mins, 5 times per day for 14 days. Salivary pellicle morphology was assessed by atomic force microscopy (AFM). Crystal characteristics, percentage microhardness loss (%SMHL), surface loss, and surface morphology were assessed by X-ray diffraction (XRD), microhardness test, profilometry, and scanning electron microscopy (SEM), respectively.
RESULTS
AFM revealed a modified pellicle morphology in Group SDF+SP. XRD of both blocks revealed hydroxyapatite, silver chloride, silver phosphate, and silver fluoride in Groups SDF+SP and SDF. Fluoroapatite was found in Group SDF+SP only. %SMHL ( ± Standard deviation in %) of Groups SDF+SP, SDF, DW+SP, and DW were 33.4 ± 2.2, 38.6 ± 2.2, 50.3 ± 2.2, and 58.3 ± 2.4 in enamel and 16.1 ± 2.2, 19.7 ± 2.1, 32.8 ± 2.1, and 39.0 ± 2.3 in dentin, respectively. The presence of SDF and SP reduced %SMHL in both blocks (p < 0.001). The surface loss ( ± Standard deviation in μm) of Groups SDF+SP, SDF, DW+SP, and DW were 3.6 ± 0.7, 4.1 ± 0.4, 5.3 ± 0.5, and 7.0 ± 0.6 in enamel and 5.4 ± 0.6, 6.1 ± 0.5, 9.1 ± 0.7, and 9.2 ± 0.5 in dentin, respectively. The presence of SDF and SP reduced surface loss in enamel and dentin blocks (p = 0.031 and p = 0.002, respectively). SEM showed enamel surface remained relatively smooth and partially dentinal tubule occlusion on dentin blocks in Groups SDF+SP and SDF.
CONCLUSION
SDF had a positively synergistic effect with SP. SDF-modified salivary pellicle provided a superior protective effect against dental erosion.
目的
研究氟化亚锡（SDF）改性唾液薄膜（SP）对牙侵蚀的预防作用。
方法
将牙釉质和牙本质块分为4组（每组n = 30）。SDF + SP组的块体用SDF和SP处理。SDF组的块体用SDF处理。去离子水（DW）+ SP组的块体用去离子水和SP处理。DW组的块体用去离子水处理。将块体在pH 3.2下进行侵蚀性刺激2分钟，每天5次，共14天。通过原子力显微镜（AFM）评估唾液薄膜形态。分别通过X射线衍射（XRD）、显微硬度测试、轮廓仪和扫描电子显微镜（SEM）评估晶体特征、显微硬度损失百分比（%SMHL）、表面损失和表面形态。
结果
AFM显示SDF + SP组的薄膜形态发生了改变。两组块体的XRD均显示SDF + SP组和SDF组中有羟基磷灰石、氯化银、磷酸银和氟化银。仅在SDF + SP组中发现了氟磷灰石。SDF + SP组、SDF组、DW + SP组和DW组在牙釉质中的%SMHL（±标准差，%）分别为33.4±2.2、38.6±2.2、50.3±2.2和58.3±2.4，在牙本质中的分别为16.1±2.2、19.7±2.1、32.8±2.1和39.0±2.3。SDF和SP的存在降低了两组块体中的%SMHL（p < 0.001）。SDF + SP组、SDF组、DW + SP组和DW组在牙釉质中的表面损失（±标准差，μm）分别为3.6±0.7、4.1±0.4、5.3±0.5和7.0±0.6，在牙本质中的分别为5.4±0.6、6.1±0.5、9.1±0.7和9.2±0.5。SDF和SP的存在减少了牙釉质和牙本质块体中的表面损失（分别为p = 0.031和p = 0.002）。SEM显示SDF + SP组和SDF组中牙釉质表面相对光滑，牙本质块体上部分牙本质小管闭塞。
结论
SDF与SP具有正协同作用。SDF改性唾液薄膜对牙侵蚀具有更好的保护作用。
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