银氨氟化溶液预防釉质侵蚀：一项有唾液膜的体外研究。

Silver diamine fluoride in preventing enamel erosion: An in vitro study with salivary pellicle.

机构信息

Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

出版信息

J Dent. 2024 Oct;149:105287. doi: 10.1016/j.jdent.2024.105287. Epub 2024 Aug 3.

DOI:10.1016/j.jdent.2024.105287

PMID:39103075

Abstract

OBJECTIVES

To compare the prevention of enamel erosion and discolouring effect with a single and two weekly topical applications of silver diamine fluoride (SDF) solution.

METHODS

Human enamel blocks were divided into four groups. Group 1 (SDF2) received two weekly applications of SDF solution (Advantage Arrest: 260,000 ppm Ag, 44,300 ppm F, pH 9.1). Group 2 (SDF1) received a single application of SDF solution. Group 3 (SNF, Positive Control) received daily application of stannous-chloride/amine-fluoride/sodium-fluoride solution (Elmex® Enamel professional: 800 ppm Sn(II), 500 ppm F, pH 4.5). Group 4 (DW, Negative Control) received daily application of deionised water. The treated blocks were subjected to a 14-day erosive challenge. Crystal characteristics, elemental composition, surface morphology, percentage of surface microhardness loss (%SMHL), surface loss, and total colour change (ΔE) of the blocks were investigated using X-ray diffraction (XRD), energy-dispersive spectrometry (EDS) and scanning electron microscopy (SEM), Vickers' hardness testing, non-contact profilometry, and digital spectrophotometry, respectively.

RESULTS

XRD and EDS revealed precipitates of silver for SDF2 and SDF1 and tin for SNF. SEM showed prominent etched enamel pattern on DW than the other three groups. The%SMHL (%) of SDF2, SDF1, SNF, and DW were 26.6 ± 2.9, 33.6 ± 2.8, 38.9 ± 2.9, and 50.5 ± 2.8 (SDF2<SDF1<SNF<DW, p < 0.001). Surface loss (μm) of SDF2, SDF1, SNF, and DW were 3.1 ± 0.6, 3.9 ± 0.6, 3.9 ± 0.7, and 5.5 ± 0.8 (SDF2<SDF1=SNF<DW, p < 0.05). Colour change of SDF2, SDF1, SNF, and DW were 7.9 ± 3.9, 4.0 ± 3.6, 3.6 ± 3.5, and -4.4 ± 3.9 (SDF2>SDF1=SNF>DW, p < 0.05).

CONCLUSION

Two weekly applications was more effective than a single application of SDF in preventing enamel erosion, though it caused more discolouration.

CLINICAL SIGNIFICANCE

Topical application of 38 % SDF with two weekly applications protocol is effective in preventing enamel erosion.

摘要

目的

比较单次和每周两次应用银胺氟化物（SDF）溶液预防釉质侵蚀和变色的效果。

方法

将人釉质块分为四组。第 1 组（SDF2）接受每周两次 SDF 溶液（Advantage Arrest：260000ppmAg，44300ppmF，pH9.1）。第 2 组（SDF1）接受单次 SDF 溶液处理。第 3 组（SNF，阳性对照）接受每天应用氯化锡/胺氟化物/氟化钠溶液（Elmex®Enamelprofessional：800ppmSn（II），500ppmF，pH4.5）。第 4 组（DW，阴性对照）接受每天应用去离子水。处理后的块体进行为期 14 天的侵蚀挑战。使用 X 射线衍射（XRD）、能量色散光谱（EDS）和扫描电子显微镜（SEM）、维氏硬度测试、非接触式轮廓仪和数字分光光度计分别研究块体的晶体特性、元素组成、表面形貌、表面显微硬度损失百分比（%SMHL）、表面损失和总色差（ΔE）。

结果

XRD 和 EDS 显示 SDF2 和 SDF1 有银沉淀，SNF 有锡沉淀。SEM 显示 DW 的釉质蚀刻图案比其他三组明显。SDF2、SDF1、SNF 和 DW 的%SMHL（%）分别为 26.6±2.9、33.6±2.8、38.9±2.9 和 50.5±2.8（SDF2<SDF1<SNF<DW，p<0.001）。SDF2、SDF1、SNF 和 DW 的表面损失（μm）分别为 3.1±0.6、3.9±0.6、3.9±0.7 和 5.5±0.8（SDF2<SDF1=SNF<DW，p<0.05）。SDF2、SDF1、SNF 和 DW 的颜色变化分别为 7.9±3.9、4.0±3.6、3.6±3.5 和-4.4±3.9（SDF2>SDF1=SNF<DW，p<0.05）。