Tan Yahong, Liu Wenjia, Li Yanhua, Zhang Nan, Wang Mingxiao, Sun Shuo, Ma Lin
Medical School of Chinese PLA, Beijing, China.
Department of Radiology, First Medical Center, Chinese PLA General Hospital, 28 Fuxing Road, 100853, Beijing, China.
Clin Neuroradiol. 2025 Mar;35(1):159-164. doi: 10.1007/s00062-024-01467-3. Epub 2024 Oct 30.
The purpose of this study is to measure the brain temperature (T) by using H magnetic resonance spectroscopy (H MRS) thermometry and investigate its age and gender differences in healthy adults. The brain temperature was further compared with the body temperature (T) to investigate the possible existence of brain-body temperature gradient (∆T).
A total of 80 subjects were included in this study. H MRS data were collected on a 3.0T MR scanner using Point Resolved Selective Spectroscopy (PRESS) sequence. Voxels were positioned in the right frontal (RF) lobe and left frontal (LF) lobe, respectively. The temperature of each voxel was calculated by chemical shift difference (∆δ) between HO and NAA which was obtained by LCModel software. The average temperature of bilateral frontal lobe voxels was defined as T for each subject. The average forehead temperature was acquired before MR scanning, defined as T, in this study. The difference between T and T, denoted as the brain-body temperature gradient (∆T), was calculated. Age and gender characteristics of T, ∆T and T were analyzed.
T (38.51 ± 0.59℃) was higher than T (36.47 ± 0.26℃) (P < 0.05). Negative correlations were observed between T and age (r = -0.49, P < 0.05) and between ∆T and age (r = -0.44, P < 0.05), whereas no correlation existed between T and age (r = -0.03, P = 0.79).
Our observation demonstrated that the brain temperature, derived from H MRS thermometry, is significantly higher than the body temperature, indicating the existence of a brain-body temperature gradient, and the brain temperature gradually decreases with age.
本研究旨在利用氢磁共振波谱（¹H MRS）测温法测量脑温（T），并探讨其在健康成年人中的年龄和性别差异。进一步将脑温与体温（Tₐ）进行比较，以研究脑 - 体温度梯度（∆T）的可能存在情况。
本研究共纳入80名受试者。使用点分辨选择性波谱（PRESS）序列在3.0T MR扫描仪上采集¹H MRS数据。体素分别置于右侧额叶（RF）和左侧额叶（LF）。通过LCModel软件获得的H₂O和NAA之间的化学位移差（∆δ）计算每个体素的温度。将双侧额叶体素的平均温度定义为每个受试者的T。在本研究中，在MR扫描前获取前额平均温度，定义为Tₐ。计算T与Tₐ之间的差值，记为脑 - 体温度梯度（∆T）。分析T、∆T和Tₐ的年龄和性别特征。
T（38.51 ± 0.59℃）高于Tₐ（36.47 ± 0.26℃）（P < 0.叭）。观察到T与年龄之间存在负相关（r = -0.49，P < 0.叭），∆T与年龄之间存在负相关（r = -0.44，P < 0.叭），而Tₐ与年龄之间无相关性（r = -0.03，P = 0.79）。
我们的观察表明，源自¹H MRS测温法的脑温显著高于体温，表明存在脑 - 体温度梯度，且脑温随年龄逐渐降低。
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