意大利威尼托地区维生素 D 检测的性别差异：2005 年至 2016 年的回顾性分析。

Sex-related differences in vitamin D testing in the Veneto Region, Italy: a retrospective analysis from 2005 to 2016.

机构信息

Clinica Medica 1, Department of Medicine, University of Padova, Padua, Italy.

Institute of Clinical Physiology (IFC), National Research Council (CNR), Rome, Italy.

出版信息

Arch Osteoporos. 2024 Oct 30;19(1):105. doi: 10.1007/s11657-024-01460-w.

DOI:10.1007/s11657-024-01460-w

PMID:39477860

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11525240/

Abstract

UNLABELLED

A retrospective analysis was performed to evaluate the frequency of vitamin D blood testing in individuals from the Padua province, Veneto, Italy from 2005 to 2016. A significant increase in the frequency of vitamin D blood tests, particularly in females was observed and in individuals with severe vitamin D deficiency (Class I).

PURPOSE

Vitamin D deficiency has been linked to negative health outcomes that extend beyond bone-related conditions. The frequency of vitamin D blood testing in residents from the Padua province, (Veneto, Italy) from 2005 to 2016 was evaluated.

METHODS

Data were retrospectively retrieved from blood test databases (Laboratory Medicine Unit, Padua University Hospital) and information on number of vitamin D blood tests performed on residents from 2005 to 2016 was collected. Data were stratified by sex and ten birth cohorts from 1901 to 2016. Blood tests were classified into five vitamin D classes: I < 50 nmol/L, II 50-74.9 nmol/L, III 75-149 nmol/L, IV 150-250 nmol/L, and V > 250-1000 nmol/L. Blood test trends were analyzed as blood test rate and vitamin D class rate/resident population. Population analysis was analyzed by incidence rates and stratified by vitamin D class.

RESULTS

293,013 vitamin D blood tests were conducted between 2005 and 2016 across 10 birth cohorts. Females accounted for 75% of tests and fewer were conducted in the youngest and oldest birth cohorts. Sex differences in vitamin D blood test frequency were observed; adjusted rates ranging from 1.7 to 35.6% for males and 8 to 81% for females from 2005 to 2016. Crude incidence rates (per 1000 from 2005 to 2016) varied from 1.5 to 10.8‰ for males and 7 to 19.4‰ for females. Crude blood test rates for vitamin D deficiency (Class I) increased from 1.1 to 9.9‰ in 2016 for males and 5 to 17.3‰ for females. Crude incidence rates (from 2005 to 2016) for Class I were 9.7-57.1‰ in males and 43.6-92.4‰ in females.

CONCLUSIONS

These findings highlight sex-related differences in vitamin D testing, providing valuable insight for healthcare planning.

摘要

未标注

对 2005 年至 2016 年期间意大利威尼托大区帕多瓦省个体的维生素 D 血液检测频率进行了回顾性分析。观察到维生素 D 血液检测的频率显著增加，尤其是在女性和严重维生素 D 缺乏症（I 类）患者中。

目的

维生素 D 缺乏与超出骨骼相关疾病的负面健康结果有关。评估了 2005 年至 2016 年期间帕多瓦省（威尼托大区，意大利）居民的维生素 D 血液检测频率。

方法

从血液检测数据库（帕多瓦大学医院检验科）中回顾性检索数据，并收集了 2005 年至 2016 年期间对居民进行的维生素 D 血液检测数量的信息。数据按性别和 1901 年至 2016 年的 10 个出生队列分层。血液检测分为五类维生素 D 类：I < 50 nmol/L、II 50-74.9 nmol/L、III 75-149 nmol/L、IV 150-250 nmol/L 和 V > 250-1000 nmol/L。分析了血液检测趋势，包括血液检测率和维生素 D 类率/居民人口。通过发病率分析了人群分析，并按维生素 D 类进行了分层。

结果

2005 年至 2016 年期间进行了 293013 次维生素 D 血液检测，涉及 10 个出生队列。女性占检测的 75%，而最年轻和最年长的出生队列中进行的检测较少。观察到维生素 D 血液检测频率的性别差异；2005 年至 2016 年期间，男性调整后的检测率范围为 1.7%至 35.6%，女性为 8%至 81%。2005 年至 2016 年期间，男性的粗发病率（每 1000 人）为 1.5 至 10.8‰，女性为 7 至 19.4‰。2016 年男性维生素 D 缺乏症（I 类）的粗血液检测率从 1.1%升至 9.9%，女性从 5%升至 17.3%。2005 年至 2016 年期间，男性 I 类的粗发病率为 9.7-57.1‰，女性为 43.6-92.4‰。