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牡荆素抗肿瘤作用及其机制的研究进展

Progress in the study of anti-tumor effects and mechanisms of vitexin.

作者信息

Yang Qiming, Huan Rui, Meng Defeng, Qi Junwei, Xia Lei

机构信息

School of Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

出版信息

Pharmacol Rep. 2025 Feb;77(1):124-134. doi: 10.1007/s43440-024-00664-8. Epub 2024 Oct 31.

Abstract

Vitexin (apigenin-8-C-beta-D-glucopyranoside) is a natural flavonoid derivative with anti-cancer, antioxidant, anti-inflammatory, antihypertensive, anti-asthma, anti-epilepsy, and other therapeutic effects. It is extracted from pearl millet, hawthorn, pigeon bean, mung bean, and other medicinal plants. Vitexin has received widespread attention because of its significant anti-tumor effect. It induces apoptosis and anti-tumor angiogenesis, inhibits tumor cell migration and invasion, regulates tumor cell autophagy and immunity, and increases patient sensitivity to radiotherapy and chemotherapy. It has a significant anti-tumor effect on breast, prostate, liver, cervical, and colon cancers, gliomas, and other malignant tumors. This review demonstrates the latest research progress on the anti-tumor effects and potential mechanisms of vitexin. It summarizes its anti-tumor mechanism to provide new theoretical support and reference for cancer treatment.

摘要

牡荆素(芹菜素-8-C-β-D-葡萄糖苷)是一种天然黄酮类衍生物,具有抗癌、抗氧化、抗炎、降压、抗哮喘、抗癫痫等治疗作用。它从珍珠粟、山楂、木豆、绿豆等药用植物中提取。由于其显著的抗肿瘤作用,牡荆素受到了广泛关注。它诱导细胞凋亡和抗肿瘤血管生成,抑制肿瘤细胞迁移和侵袭,调节肿瘤细胞自噬和免疫,并增加患者对放疗和化疗的敏感性。它对乳腺癌、前列腺癌、肝癌、宫颈癌、结肠癌、神经胶质瘤等恶性肿瘤具有显著的抗肿瘤作用。本文综述了牡荆素抗肿瘤作用及潜在机制的最新研究进展。总结其抗肿瘤机制,为癌症治疗提供新的理论支持和参考。

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