Ganesan Kumar, Xu Baojun
Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, Guangdong, China.
Ann N Y Acad Sci. 2017 Aug;1401(1):102-113. doi: 10.1111/nyas.13446.
Cancer is a primary public health problem and the second leading cause of death worldwide. It causes life-threatening malignancies and results in high financial costs for both patients and the healthcare system. Hence, it is important to develop effective long-term strategies pertaining to prevention and control of cancers. Plant-derived secondary metabolites have been shown to have positive roles against various cancers. A number of plant extracts have been evaluated for possible use in the treatment of cancer; some have provided direction for new strategies for the research and development of antitumor agents. Here, we provide comprehensive data on various cancers, potential molecular mechanisms, and therapeutic implications of just two plant-derived compounds, vitexin and isovitexin. Information on the chemotherapeutic potential of vitexin and isovitexin was collected from a library database and through electronic searches (ScienceDirect, Pubmed, and Google Scholar). Both in vitro and in vivo studies suggest that vitexin and isovitexin are chemopreventive compounds with activity against various cancers through proapoptotic processes and/or autophagy.
癌症是一个主要的公共卫生问题，是全球第二大死因。它会引发危及生命的恶性肿瘤，给患者和医疗系统都带来高昂的经济成本。因此，制定有效的癌症预防和控制长期策略非常重要。植物来源的次生代谢产物已被证明对各种癌症具有积极作用。许多植物提取物已被评估用于癌症治疗的可能性；一些提取物为抗肿瘤药物的研发新策略提供了方向。在此，我们提供了关于两种植物来源的化合物——牡荆素和异牡荆素——对各种癌症的潜在分子机制及治疗意义的全面数据。关于牡荆素和异牡荆素化疗潜力的信息是从图书馆数据库以及通过电子搜索（ScienceDirect、PubMed和谷歌学术）收集而来的。体外和体内研究均表明，牡荆素和异牡荆素是具有化学预防作用的化合物，通过促凋亡过程和/或自噬对各种癌症具有活性。
