State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 511436, Guangdong, P. R. China.
College of Pharmacy, Jinan University, Guangzhou, 511436, Guangdong, P. R. China.
Pharm Res. 2024 Nov;41(11):2121-2141. doi: 10.1007/s11095-024-03790-3. Epub 2024 Oct 30.
To explore the potential of transnasal drug delivery systems (DDS) as an effective means of bypassing the bloodbrain barrier (BBB) for enhanced central nervous system (CNS) targeting, aiming to improve therapeutic outcomes for CNS disorders while reducing systemic side effects.
A review of current and emerging DDS technologies, including polymer nanoparticles, liposomes, and micelles, was conducted to assess their suitability for precision-targeted delivery to the brain through the transnasal route.
The investigated DDS demonstrate promising capabilities for CNS targeting via the nasal pathway, effectively preserving both the nasal mucosa and CNS integrity. These systems enhance drug precision within neural tissues, potentially improving therapeutic outcomes without harming adjacent tissues.
Transnasal DDS offer a promising alternative to traditional delivery methods, with significant potential to advance the treatment of cerebrovascular diseases, neurodegenerative disorders, brain tumors, and psychiatric conditions. This approach represents an evolving frontier in neurotherapeutics, with the potential to transform CNS drug delivery practices.
探索经鼻给药系统（DDS）作为一种绕过血脑屏障（BBB）的有效手段，以增强中枢神经系统（CNS）靶向性，旨在改善中枢神经系统疾病的治疗效果，同时减少全身副作用。
对当前和新兴的 DDS 技术，包括聚合物纳米粒子、脂质体和胶束进行了综述，以评估它们通过经鼻途径精确靶向递送到大脑的适用性。
研究的 DDS 通过鼻腔途径对 CNS 具有有前景的靶向能力，能够有效地保护鼻腔黏膜和 CNS 完整性。这些系统在神经组织内增强了药物的靶向性，有可能在不损害相邻组织的情况下改善治疗效果。
经鼻 DDS 为传统给药方法提供了一种有前途的替代方案，在治疗脑血管疾病、神经退行性疾病、脑肿瘤和精神疾病方面具有显著的潜力。这种方法代表了神经治疗学的一个发展前沿，有可能改变 CNS 药物输送的实践。
