Department of Anesthesiology, The Second Affliated Hospital, Jiangxi Medical College, Nanchang University, 1# Minde Road, Nanchang, 330006, Jiangxi Privince, People's Republic of China.
The First Hospital of Xiushui, Jiujiang, Jiangxi Province, People's Republic of China.
Sci Rep. 2024 Oct 30;14(1):26112. doi: 10.1038/s41598-024-75284-6.
With the aging process of the global population and the development of medical technology, the cases of postoperative cognitive dysfunction (POCD) are also increasing. Due to the complexity of the pathogenesis, urgent treatment has been sought. Neuroinflammation induced by the accumulation of lipid droplets (LDs) in microglia has been closely watched in recent years and is also considered to be an important cause of nerve damage. Our study found that derived from Withania somnifera, Withaferin A (WA) could reduce the accumulation of LDs in the hippocampus of POCD mice, inhibit the expression of inflammatory factor interleukin-1β (IL-1β), and improve the cognitive ability of mice. Further in vitro experimental studies showed that WA increased the autophagy level of microglia, promoted the degradation of LDs, and reduced the production of inflammatory factors. In this regard, our comprehensive research endeavor holds the potential to furnish novel insights into therapeutic strategies aimed at addressing POCD and its associated neural impairments.
随着全球人口老龄化和医疗技术的发展，术后认知功能障碍（POCD）的病例也在增加。由于发病机制复杂，人们迫切寻求紧急治疗。近年来，人们密切关注小胶质细胞中脂滴（LDs）积累引起的神经炎症，这也被认为是神经损伤的一个重要原因。我们的研究发现，从睡茄中提取的 Withaferin A（WA）可以减少 POCD 小鼠海马中 LDs 的积累，抑制炎症因子白细胞介素-1β（IL-1β）的表达，提高小鼠的认知能力。进一步的体外实验研究表明，WA 增加了小胶质细胞的自噬水平，促进了 LDs 的降解，减少了炎症因子的产生。在这方面，我们的综合研究努力有可能为治疗 POCD 及其相关神经损伤提供新的治疗策略。
