Department of Joint Surgery, The Affiliated Hospital of Qingdao University, No. 59, Haier Road, Qingdao, 266003, China.
Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
J Transl Med. 2024 Oct 30;22(1):982. doi: 10.1186/s12967-024-05784-6.
Osteonecrosis of the femoral head (ONFH) significantly impacts young and middle-aged adults, with steroid use implicated in many cases. Traditional treatments have limited efficacy, prompting a shift towards innovative approaches, such as stem cell therapy, offering less invasive regenerative solutions.
Using bibliometric analysis from 1997 to 2023, we identified 392 articles on stem cell therapy for ONFH from the Web of Science Core Collection and analysed them using VOSviewer and CiteSpace to identify key trends and research directions.
From 1997 to 2023, stem cell therapy for ONFH research expanded significantly, with 392 articles evidencing global collaboration, particularly from China, the United States and South Korea. The field is characterised by 158 core authors across 26 clusters and contributions from 417 institutions in 104 research clusters, with Shanghai Jiao Tong University as a notable leader. This research is disseminated through 23 journal clusters, emphasising interdisciplinary work, with Clinical Orthopaedics and Related Research among the most influential journals. Key findings include the identification of the most influential papers, highlighting advances, such as use of autologous mesenchymal stem cells (MSCs) and innovative delivery mechanisms. High-frequency keyword analysis further mapped the evolution of the field, from basic mechanisms to advanced therapies, underscoring a trend towards more targeted stem cell treatments for ONFH.
Stem cell therapy for ONFH has advanced significantly, showcasing a successful transition from basic research to clinical practice, particularly highlighted by developments in use of autologous MSCs and delivery methods. Future research will focus on refining therapies through exosome technology, targeted modulation of stress and inflammation and integration with surgical techniques, with the aim of tailored patient care and improved ONFH outcomes.
股骨头坏死（ONFH）严重影响中青年人群，许多病例与激素使用有关。传统治疗方法疗效有限，促使人们转向创新方法，如干细胞疗法，提供微创再生解决方案。
我们使用文献计量分析方法，从 1997 年到 2023 年，从 Web of Science 核心合集数据库中确定了 392 篇关于干细胞治疗 ONFH 的文章，并使用 VOSviewer 和 CiteSpace 对其进行分析，以确定关键趋势和研究方向。
从 1997 年到 2023 年，ONFH 的干细胞治疗研究显著扩展，有 392 篇文章证明了全球合作，特别是来自中国、美国和韩国的合作。该领域有 158 位核心作者，分布在 26 个聚类中，来自 417 个机构的 417 位作者在 104 个研究聚类中做出了贡献，其中上海交通大学是一个显著的领导者。这项研究通过 23 个期刊聚类进行传播，强调跨学科工作，其中《临床骨科与相关研究》是最有影响力的期刊之一。主要发现包括确定最有影响力的论文，突出了进展，如使用自体间充质干细胞（MSCs）和创新的输送机制。高频关键词分析进一步绘制了该领域的演变图，从基础机制到先进疗法，强调了针对 ONFH 的更有针对性的干细胞治疗趋势。
ONFH 的干细胞治疗有了显著的进步，展示了从基础研究到临床实践的成功转变，特别是自体 MSCs 的使用和输送方法的发展。未来的研究将集中在通过外泌体技术、靶向调节应激和炎症以及与手术技术相结合来改进疗法，以实现针对患者的护理和改善 ONFH 结果。
