School of Basic Medical Sciences, Naval Medical University, No 800. Xiangyin Road, Yangpu, Shanghai, 200433, China.
Department of Nephrology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, Hubei, China.
Lipids Health Dis. 2024 Oct 30;23(1):353. doi: 10.1186/s12944-024-02338-z.
Abnormalities in lipid metabolism are common among adult asthmatics. However, the precise directionality linking asthma to blood lipid levels remains controversial. Our study aimed to evaluate the association between the Non-HDL to HDL Ratio (NHHR), a lipid composite index, and asthma prevalence among the adult population in the United States.
Utilizing adult participants' data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2009 to 2018, the study employed a multivariable logistic regression model, adjusting for covariables, to establish the relationship between NHHR levels and the prevalence of asthma. Furthermore, smoothing curve fitting and subgroup analyses were conducted to investigate the robustness of this association.
This study included 26,023 adult individuals (mean age = 49.63 ± 17.66). In the fully adjusted model, a significant inverse association was observed between log-transformed NHHR values and asthma prevalence (OR = 0.85, 95% CI: 0.79-0.93). Subgroup analysis revealed that gender served as a modulator, altering the association between NHHR levels and asthma prevalence. A more pronounced negative association between lnNHHR and asthma prevalence was noted among male participants [(Male: OR = 0.78, 95% CI: 0.69-0.88) vs. (Female: OR = 0.92, 95% CI: 0.83-1.03), P for interaction = 0.0313].
Our study revealed an inverse association between NHHR levels and the prevalence of asthma in the US adult population, which is influenced by gender. NHHR measurement may be a potential tool for early identification and prediction of adult asthmatics in specific populations.
脂质代谢异常在成年哮喘患者中很常见。然而，将哮喘与血脂水平联系起来的确切方向仍存在争议。我们的研究旨在评估非高密度脂蛋白胆固醇（Non-HDL）与高密度脂蛋白胆固醇（HDL）比值（NHHR），一种脂质综合指数，与美国成年人群中哮喘患病率之间的关系。
利用美国国家健康和营养调查（NHANES）2009 年至 2018 年期间成年参与者的数据，本研究采用多变量逻辑回归模型，调整协变量，建立 NHHR 水平与哮喘患病率之间的关系。此外，进行平滑曲线拟合和亚组分析，以探究该关联的稳健性。
本研究纳入了 26023 名成年个体（平均年龄 49.63±17.66 岁）。在完全调整模型中，log 转化后的 NHHR 值与哮喘患病率之间存在显著的负相关关系（OR=0.85，95%CI：0.79-0.93）。亚组分析显示，性别是一个调节因素，改变了 NHHR 水平与哮喘患病率之间的关联。在男性参与者中，lnNHHR 与哮喘患病率之间的负相关关系更为明显[（男性：OR=0.78，95%CI：0.69-0.88）与（女性：OR=0.92，95%CI：0.83-1.03），P 交互=0.0313]。
我们的研究揭示了 NHHR 水平与美国成年人群中哮喘患病率之间的负相关关系，这种关系受到性别的影响。NHHR 测量可能是特定人群中识别和预测成年哮喘患者的潜在工具。
