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更好地准备:加速 COVID-19 治疗干预和疫苗(ACTIV)治疗试验的经验教训:对未来的呼吁。

Preparing better: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) therapeutics trials lessons learned: A call to the future.

作者信息

Adam Stacey J, Buchman Timothy G, Currier Judith S, Draghia-Akli Ruxandra, Fessel Josh P, Higgs Elizabeth S, Hughes Eric A, LaVange Lisa, Menetski Joseph P, Read Sarah W, Rosenberg Yves, Tressler Randall

机构信息

Foundation for the National Institutes of Health, North Bethesda, MD, USA.

Critical Care Center, Emory University School of Medicine, Atlanta, GA, USA.

出版信息

J Clin Transl Sci. 2024 Oct 15;8(1):e150. doi: 10.1017/cts.2024.178. eCollection 2024.

Abstract

The Accelerating COVID-19 Therapeutic Interventions and Vaccines Therapeutic-Clinical Working Group members gathered critical recommendations in follow-up to lessons learned manuscripts released earlier in the COVID-19 pandemic. Lessons around agent prioritization, preclinical therapeutics testing, master protocol design and implementation, drug manufacturing and supply, data sharing, and public-private partnership value are shared to inform responses to future pandemics.

摘要

加速 COVID-19 治疗干预和疫苗治疗临床工作组的成员在 COVID-19 大流行早期发布的经验教训手稿后续工作中收集了关键建议。围绕药物优先排序、临床前治疗测试、主方案设计与实施、药品生产与供应、数据共享以及公私伙伴关系价值等方面的经验进行了分享,以为应对未来大流行提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23e8/11523022/c08b68bfe1c5/S205986612400178X_fig1.jpg

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