Lei Junfang, Li Xu, Xue Wenbo, Qian Xinrui, Wang Tong, Xiang Yunuo, Zhang Yangchun, Chen Meixing, Liu Zhaohui
Department of Otorhinolaryngology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Front Med (Lausanne). 2024 Oct 16;11:1450526. doi: 10.3389/fmed.2024.1450526. eCollection 2024.
This meta-analysis aimed to evaluate the comparative diagnostic accuracy of [F]FDG PET/CT versus [F]FDG PET/MRI in identifying lymph node metastases in individuals with nasopharyngeal carcinoma.
A comprehensive search was executed across PubMed, Embase, and Web of Science through September 2023 to identify studies evaluating the diagnostic precision of [F]FDG PET/CT and [F]FDG PET/MRI in detecting lymph node metastasis in nasopharyngeal carcinoma. Sensitivity and specificity were assessed through the DerSimonian-Laird method, incorporating the Freeman-Tukey transformation.
The meta-analysis encompassed nine articles, involving a total of 916 patients. The overall sensitivity and specificity of [F]FDG PET were 0.95 (95%CI: 0.88-1.00) and 0.95 (95%CI: 0.84-1.00). The overall sensitivity of [F]FDG PET/CT was 0.94 (95%CI, 0.85-0.99), whereas [F]FDG PET/MRI achieved a sensitivity of 1.00 (95%CI, 0.94-1.00). The findings reveal that [F]FDG PET/CT demonstrates comparable sensitivity to [F]FDG PET/MRI ( = 0.20). The overall specificity of [F]FDG PET/CT was 0.94 (95%CI, 0.82-1.00), whereas [F]FDG PET/MRI exhibited a specificity of 0.98 (95%CI, 0.93-1.00). Additionally, the results suggest that [F]FDG PET/CT offers similar specificity to [F]FDG PET/MRI ( = 0.11).
[F]FDG PET demonstrates high sensitivity and specificity in identifying lymph node metastasis in nasopharyngeal carcinoma. Furthermore, [F]FDG PET/CT exhibits comparable sensitivity and specificity to [F]FDG PET/MRI.
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=496006, PROSPERO (CRD42024496006).
本荟萃分析旨在评估[F]FDG PET/CT与[F]FDG PET/MRI在鼻咽癌患者中识别淋巴结转移的比较诊断准确性。
截至2023年9月，在PubMed、Embase和Web of Science上进行了全面检索，以确定评估[F]FDG PET/CT和[F]FDG PET/MRI在检测鼻咽癌淋巴结转移方面诊断准确性的研究。通过DerSimonian-Laird方法并结合Freeman-Tukey变换评估敏感性和特异性。
该荟萃分析纳入了9篇文章，共涉及916例患者。[F]FDG PET的总体敏感性和特异性分别为0.95（95%CI：0.88-1.00）和0.95（95%CI：0.84-1.00）。[F]FDG PET/CT的总体敏感性为0.94（95%CI，0.85-0.99），而[F]FDG PET/MRI的敏感性为1.00（95%CI，0.94-1.00）。结果显示，[F]FDG PET/CT与[F]FDG PET/MRI的敏感性相当（=0.20）。[F]FDG PET/CT的总体特异性为0.94（95%CI，0.82-1.00），而[F]FDG PET/MRI的特异性为0.98（95%CI，0.93-1.00）。此外，结果表明，[F]FDG PET/CT与[F]FDG PET/MRI的特异性相似（=0.11）。
[F]FDG PET在识别鼻咽癌淋巴结转移方面具有高敏感性和特异性。此外，[F]FDG PET/CT与[F]FDG PET/MRI的敏感性和特异性相当。
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=496006，PROSPERO（CRD42024496006）。
